The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia

Philadelphia chromosome positive B cell acute lymphoblastic leukemia (Ph+ ALL) is an aggressive cancer of the bone marrow. The addition of tyrosine kinase inhibitors (TKIs) has improved outcomes but many patients still suffer relapse and novel therapeutic agents are needed. KPC34 is an orally availa...

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Detalles Bibliográficos
Autores principales: Alexander, Peter M., Caudell, David L., Kucera, Gregory L., Pladna, Kristin M., Pardee, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482463/
https://www.ncbi.nlm.nih.gov/pubmed/28644853
http://dx.doi.org/10.1371/journal.pone.0179798

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