Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF may in addition radiosensitize tumor cells by targeting thioredoxin reductase (TrxR), a critical enzyme in the antioxida...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Bouzakoura, Soumaya, de Mey, Sven, Jiang, Heng, Law, Kalun, Dufait, Inès, Corbet, Cyril, Verovski, Valeri, Gevaert, Thierry, Feron, Olivier, Van den Berge, Dirk, Storme, Guy, De Ridder, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482612/
https://www.ncbi.nlm.nih.gov/pubmed/28415723
http://dx.doi.org/10.18632/oncotarget.16113

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