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The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy

BACKGROUND: Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of...

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Autores principales: de Mol, Mark, den Oudsten, Brenda L., Aarts, Mieke, Aerts, Joachim G.J.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482693/
https://www.ncbi.nlm.nih.gov/pubmed/28030796
http://dx.doi.org/10.18632/oncotarget.14151
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author de Mol, Mark
den Oudsten, Brenda L.
Aarts, Mieke
Aerts, Joachim G.J.V.
author_facet de Mol, Mark
den Oudsten, Brenda L.
Aarts, Mieke
Aerts, Joachim G.J.V.
author_sort de Mol, Mark
collection PubMed
description BACKGROUND: Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy. METHODS: Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study. RESULTS: In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was. CONCLUSIONS: In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue.
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spelling pubmed-54826932017-06-27 The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy de Mol, Mark den Oudsten, Brenda L. Aarts, Mieke Aerts, Joachim G.J.V. Oncotarget Clinical Research Paper BACKGROUND: Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy. METHODS: Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study. RESULTS: In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was. CONCLUSIONS: In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue. Impact Journals LLC 2016-12-24 /pmc/articles/PMC5482693/ /pubmed/28030796 http://dx.doi.org/10.18632/oncotarget.14151 Text en Copyright: © 2017 de Mol et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Clinical Research Paper
de Mol, Mark
den Oudsten, Brenda L.
Aarts, Mieke
Aerts, Joachim G.J.V.
The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy
title The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy
title_full The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy
title_fullStr The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy
title_full_unstemmed The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy
title_short The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy
title_sort distress thermometer as a predictor for survival in stage iii lung cancer patients treated with chemotherapy
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482693/
https://www.ncbi.nlm.nih.gov/pubmed/28030796
http://dx.doi.org/10.18632/oncotarget.14151
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