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Vitamin D status among long-term survivors of testicular cancer
A correlation between disturbances in hormone levels and the onset of metabolic disorders has been reported in long-term survivors of testicular cancer (TC). We evaluated serum vitamin D levels and other biological parameters in a consecutive series of 61 long-term (≥3 years) unilateral TC survivors...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482697/ https://www.ncbi.nlm.nih.gov/pubmed/28030821 http://dx.doi.org/10.18632/oncotarget.14167 |
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author | Schepisi, Giuseppe De Padova, Silvia Scarpi, Emanuela Lolli, Cristian Gurioli, Giorgia Menna, Cecilia Burgio, Salvatore L. Rossi, Lorena Gallà, Valentina Casadio, Valentina Salvi, Samanta Conteduca, Vincenza De Giorgi, Ugo |
author_facet | Schepisi, Giuseppe De Padova, Silvia Scarpi, Emanuela Lolli, Cristian Gurioli, Giorgia Menna, Cecilia Burgio, Salvatore L. Rossi, Lorena Gallà, Valentina Casadio, Valentina Salvi, Samanta Conteduca, Vincenza De Giorgi, Ugo |
author_sort | Schepisi, Giuseppe |
collection | PubMed |
description | A correlation between disturbances in hormone levels and the onset of metabolic disorders has been reported in long-term survivors of testicular cancer (TC). We evaluated serum vitamin D levels and other biological parameters in a consecutive series of 61 long-term (≥3 years) unilateral TC survivors with a median a follow-up of 4 years and in a cohort of healthy males. Deficient vitamin D levels were observed in 10 (17%) of the 58 long-term unilateral TC survivors but were not reported in healthy males (p=.019, Fisher test). Median vitamin D levels were 18.6 ug/L in 58 assessable TC survivors and 23.6 ug/L in 40 healthy males (p=.031). In univariate logistic regression analysis, TC diagnosis was associated with inadequate levels of vitamin D (p=.047). Vitamin D levels were lower when follow-up was > 10 years, albeit this difference was not statistically significant (p=.074). Long-term (especially > 10 years) TC survivors may have difficulty maintaining optimal vitamin D levels. Larger studies are needed to better characterize vitamin D status and possible correlations with premature hormonal aging reported in long-term TC survivors. |
format | Online Article Text |
id | pubmed-5482697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54826972017-06-27 Vitamin D status among long-term survivors of testicular cancer Schepisi, Giuseppe De Padova, Silvia Scarpi, Emanuela Lolli, Cristian Gurioli, Giorgia Menna, Cecilia Burgio, Salvatore L. Rossi, Lorena Gallà, Valentina Casadio, Valentina Salvi, Samanta Conteduca, Vincenza De Giorgi, Ugo Oncotarget Clinical Research Paper A correlation between disturbances in hormone levels and the onset of metabolic disorders has been reported in long-term survivors of testicular cancer (TC). We evaluated serum vitamin D levels and other biological parameters in a consecutive series of 61 long-term (≥3 years) unilateral TC survivors with a median a follow-up of 4 years and in a cohort of healthy males. Deficient vitamin D levels were observed in 10 (17%) of the 58 long-term unilateral TC survivors but were not reported in healthy males (p=.019, Fisher test). Median vitamin D levels were 18.6 ug/L in 58 assessable TC survivors and 23.6 ug/L in 40 healthy males (p=.031). In univariate logistic regression analysis, TC diagnosis was associated with inadequate levels of vitamin D (p=.047). Vitamin D levels were lower when follow-up was > 10 years, albeit this difference was not statistically significant (p=.074). Long-term (especially > 10 years) TC survivors may have difficulty maintaining optimal vitamin D levels. Larger studies are needed to better characterize vitamin D status and possible correlations with premature hormonal aging reported in long-term TC survivors. Impact Journals LLC 2016-12-24 /pmc/articles/PMC5482697/ /pubmed/28030821 http://dx.doi.org/10.18632/oncotarget.14167 Text en Copyright: © 2017 Schepisi et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Clinical Research Paper Schepisi, Giuseppe De Padova, Silvia Scarpi, Emanuela Lolli, Cristian Gurioli, Giorgia Menna, Cecilia Burgio, Salvatore L. Rossi, Lorena Gallà, Valentina Casadio, Valentina Salvi, Samanta Conteduca, Vincenza De Giorgi, Ugo Vitamin D status among long-term survivors of testicular cancer |
title | Vitamin D status among long-term survivors of testicular cancer |
title_full | Vitamin D status among long-term survivors of testicular cancer |
title_fullStr | Vitamin D status among long-term survivors of testicular cancer |
title_full_unstemmed | Vitamin D status among long-term survivors of testicular cancer |
title_short | Vitamin D status among long-term survivors of testicular cancer |
title_sort | vitamin d status among long-term survivors of testicular cancer |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482697/ https://www.ncbi.nlm.nih.gov/pubmed/28030821 http://dx.doi.org/10.18632/oncotarget.14167 |
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