Cargando…

Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study

BACKGROUND: Survival benefit from surgical debulking of ovarian cancer (OC) is well established, but some women, despite total macroscopic clearance of disease, still have poor prognosis. We aimed to identify biomarkers to predict benefit from conventional surgery. METHODS: Clinical data from women...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phelps, David L, Borley, Jane V, Flower, Kirsty J, Dina, Roberto, Darb-Esfahani, Silvia, Braicu, Ioana, Sehouli, Jalid, Fotopoulou, Christina, Wilhelm-Benartzi, Charlotte S, Gabra, Hani, Yazbek, Joseph, Chatterjee, Jayanta, Ip, Jacey, Khan, Harun, Likos-Corbett, Marina-Therese, Brown, Robert, Ghaem-Maghami, Sadaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482730/ https://www.ncbi.nlm.nih.gov/pubmed/28350786 http://dx.doi.org/10.1038/bjc.2017.83

Ejemplares similares

Does tumour biology determine surgical success in the treatment of epithelial ovarian cancer? A systematic literature review
por: Borley, J, et al.
Publicado: (2012)

Risk of Ovarian Cancer Relapse Score: A Prognostic Algorithm to Predict Relapse Following Treatment for Advanced Ovarian Cancer
por: Rizzuto, Ivana, et al.
Publicado: (2015)

Fertility-Sparing Surgery in Early Epithelial Ovarian Cancer: A Viable Option?
por: Fotopoulou, Christina, et al.
Publicado: (2012)

Overexpression of the epithelial cell adhesion molecule is associated with a more favorable prognosis and response to platinum-based chemotherapy in ovarian cancer
por: Woopen, Hannah, et al.
Publicado: (2014)

Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)—A Prospective Pilot Study of Diagnostic Accuracy
por: Marcus, Diana, et al.
Publicado: (2022)

Is ovarian cancer surgery stuck in the dark ages?: a commentary piece reviewing surgical technologies
por: Phelps, David L., et al.
Publicado: (2020)

Analysis of worldwide surgical outcomes in COVID-19-infected patients: a gynecological oncology perspective
por: Phelps, David L, et al.
Publicado: (2020)

An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas
por: Noske, Aurelia, et al.
Publicado: (2011)

Neutrophil Granulocytes in Ovarian Cancer - Induction of Epithelial-To-Mesenchymal-Transition and Tumor Cell Migration
por: Mayer, Christine, et al.
Publicado: (2016)

Prognostic impact of programmed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor-infiltrating lymphocytes in ovarian high grade serous carcinoma
por: Darb-Esfahani, Silvia, et al.
Publicado: (2015)

Checkpoint-inhibition in ovarian cancer: rising star or just a dream?
por: Pietzner, Klaus, et al.
Publicado: (2018)

NY-ESO-1 expression in DCIS: A new predictor of good prognosis
por: Coombes, R. Charles, et al.
Publicado: (2017)

Characterisation of homologous recombination deficiency in paired primary and recurrent high-grade serous ovarian cancer
por: Patel, Jai N., et al.
Publicado: (2018)

Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer
por: Kulbe, Hagen, et al.
Publicado: (2019)

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations
por: Tougas, Carson L., et al.
Publicado: (2019)

Study protocol for a randomised controlled trial on the use of intraoperative ultrasound-guided laparoscopic ovarian cystectomy (UGLOC) as a method of fertility preservation in the management of benign ovarian cysts
por: Kasaven, Lorraine S, et al.
Publicado: (2022)

Dynamics of the Intratumoral Immune Response during Progression of High-Grade Serous Ovarian Cancer()
por: Stanske, Mandy, et al.
Publicado: (2018)

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism
por: Braicu, Elena Ioana, et al.
Publicado: (2017)

Discovery of Prognostic Markers for Early-Stage High-Grade Serous Ovarian Cancer by Maldi-Imaging
por: Kulbe, Hagen, et al.
Publicado: (2020)

Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study).
por: Ruscito, Ilary, et al.
Publicado: (2018)

Sialic Acid Linkage Analysis Refines the Diagnosis of Ovarian Cancer
por: Dědová, Tereza, et al.
Publicado: (2019)

Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment
por: Hoffmann, Karen, et al.
Publicado: (2020)

Conservative management of uterine adenosarcoma: lessons learned from 20 years of follow-up
por: L’Heveder, Ariadne, et al.
Publicado: (2019)

Genetic polymorphisms of matrix metalloproteinases 1–3 and their inhibitor are not associated with premature labor
por: Lathouras, Konstantinos, et al.
Publicado: (2018)

Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer
por: Ihlow, Jana, et al.
Publicado: (2022)

Identification of MYLK3 mutations in familial dilated cardiomyopathy
por: Tobita, Takashige, et al.
Publicado: (2017)

MYLK and CALD1 as molecular targets in bladder cancer
por: Jin, Hui, et al.
Publicado: (2023)

COVID‐19 and the impact on gynecologic cancer care
por: Manchanda, Ranjit, et al.
Publicado: (2021)

The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases
por: Biskup, Karina, et al.
Publicado: (2014)

Chondroitin Sulfate Disaccharides, a Serum Marker for Primary Serous Epithelial Ovarian Cancer
por: Biskup, Karina, et al.
Publicado: (2021)

Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression
por: Natoli, Marina, et al.
Publicado: (2021)

ROCK2 and MYLK variants and high-altitude pulmonary edema
por: Sikri, Gaurav, et al.
Publicado: (2016)

Role of histological type on surgical outcome and survival following radical primary tumour debulking of epithelial ovarian, fallopian tube and peritoneal cancers
por: Braicu, E-I, et al.
Publicado: (2011)

In Situ N-Glycosylation Signatures of Epithelial Ovarian Cancer Tissue as Defined by MALDI Mass Spectrometry Imaging
por: Grzeski, Marta, et al.
Publicado: (2022)

Correction to: Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade
por: Natoli, Marina, et al.
Publicado: (2020)

Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade
por: Natoli, Marina, et al.
Publicado: (2020)

Uterine transplantation in transgender women
por: Jones, BP, et al.
Publicado: (2018)

Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging
por: Kassuhn, Wanja, et al.
Publicado: (2021)

The impact of patient compliance with adjuvant radiotherapy: a comprehensive cohort study
por: Badakhshi, Harun, et al.
Publicado: (2013)

Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
por: Lu, Haonan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ars3g997tt7430memjmm56c6eq