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Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells

Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO cells. This discrepancy in SOAT inhibition by Beau...

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Detalles Bibliográficos
Autores principales:	Ohshiro, Taichi, Kobayashi, Keisuke, Ohba, Mio, Matsuda, Daisuke, Rudel, Lawrence L., Takahashi, Takashi, Doi, Takayuki, Tomoda, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482845/ https://www.ncbi.nlm.nih.gov/pubmed/28646165 http://dx.doi.org/10.1038/s41598-017-04177-8

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