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A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics
In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped flu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482848/ https://www.ncbi.nlm.nih.gov/pubmed/28646143 http://dx.doi.org/10.1038/s41598-017-03834-2 |
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author | Zhao, Yating Wang, Yu Ran, Fu Cui, Yu Liu, Chang Zhao, Qinfu Gao, Yikun Wang, Da Wang, Siling |
author_facet | Zhao, Yating Wang, Yu Ran, Fu Cui, Yu Liu, Chang Zhao, Qinfu Gao, Yikun Wang, Da Wang, Siling |
author_sort | Zhao, Yating |
collection | PubMed |
description | In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS. |
format | Online Article Text |
id | pubmed-5482848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54828482017-06-26 A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics Zhao, Yating Wang, Yu Ran, Fu Cui, Yu Liu, Chang Zhao, Qinfu Gao, Yikun Wang, Da Wang, Siling Sci Rep Article In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS. Nature Publishing Group UK 2017-06-23 /pmc/articles/PMC5482848/ /pubmed/28646143 http://dx.doi.org/10.1038/s41598-017-03834-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhao, Yating Wang, Yu Ran, Fu Cui, Yu Liu, Chang Zhao, Qinfu Gao, Yikun Wang, Da Wang, Siling A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
title | A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
title_full | A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
title_fullStr | A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
title_full_unstemmed | A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
title_short | A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
title_sort | comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482848/ https://www.ncbi.nlm.nih.gov/pubmed/28646143 http://dx.doi.org/10.1038/s41598-017-03834-2 |
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