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Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation
We report on a 59-year-old female patient with an infected vascular graft investigated with (18)F FDG-PET/CT. The first of two studies showed FDG activity in the left deltoid and ipsilateral axillary lymph nodes explained by influenza vaccination the day prior. The second (18)F FDG-PET/CT showed mul...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Oceania Journal of Nuclear Medicine & Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482920/ https://www.ncbi.nlm.nih.gov/pubmed/28660226 http://dx.doi.org/10.22038/aojnmb.2017.8702 |
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author | Ayati, Narjess Jesudason, Sarah Berlangieri, Salvatore U. Scott, Andrew M. |
author_facet | Ayati, Narjess Jesudason, Sarah Berlangieri, Salvatore U. Scott, Andrew M. |
author_sort | Ayati, Narjess |
collection | PubMed |
description | We report on a 59-year-old female patient with an infected vascular graft investigated with (18)F FDG-PET/CT. The first of two studies showed FDG activity in the left deltoid and ipsilateral axillary lymph nodes explained by influenza vaccination the day prior. The second (18)F FDG-PET/CT showed multiple FDG-avid lymph nodes on both sides of the diaphragm without tracer accumulation at the vaccination site. Three months later the CT was negative for lymphadenopathy within the chest or abdominal region. Although influenza vaccination is a potential source of false positive results in FDG PET studies, generalised lymph node activation post vaccination is a rare finding with only one prior published report in individuals infected with HIV-1. This case emphasizes the necessity of taking a history of vaccination prior to a FDG PET study, and consideration of a vaccine-related immune response even without evidence of tracer activity at the vaccination site when generalised FDG-avid lymphadenopathy is encountered. |
format | Online Article Text |
id | pubmed-5482920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Asia Oceania Journal of Nuclear Medicine & Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-54829202017-06-28 Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation Ayati, Narjess Jesudason, Sarah Berlangieri, Salvatore U. Scott, Andrew M. Asia Ocean J Nucl Med Biol Case Report We report on a 59-year-old female patient with an infected vascular graft investigated with (18)F FDG-PET/CT. The first of two studies showed FDG activity in the left deltoid and ipsilateral axillary lymph nodes explained by influenza vaccination the day prior. The second (18)F FDG-PET/CT showed multiple FDG-avid lymph nodes on both sides of the diaphragm without tracer accumulation at the vaccination site. Three months later the CT was negative for lymphadenopathy within the chest or abdominal region. Although influenza vaccination is a potential source of false positive results in FDG PET studies, generalised lymph node activation post vaccination is a rare finding with only one prior published report in individuals infected with HIV-1. This case emphasizes the necessity of taking a history of vaccination prior to a FDG PET study, and consideration of a vaccine-related immune response even without evidence of tracer activity at the vaccination site when generalised FDG-avid lymphadenopathy is encountered. Asia Oceania Journal of Nuclear Medicine & Biology 2017 /pmc/articles/PMC5482920/ /pubmed/28660226 http://dx.doi.org/10.22038/aojnmb.2017.8702 Text en Copyright: © 2017 mums.ac.ir http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ayati, Narjess Jesudason, Sarah Berlangieri, Salvatore U. Scott, Andrew M. Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation |
title | Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation |
title_full | Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation |
title_fullStr | Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation |
title_full_unstemmed | Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation |
title_short | Generalized Lymph Node Activation after Influenza Vaccination on (18)F FDG-PET/CT Imaging, an Important Pitfall in PET Interpretation |
title_sort | generalized lymph node activation after influenza vaccination on (18)f fdg-pet/ct imaging, an important pitfall in pet interpretation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482920/ https://www.ncbi.nlm.nih.gov/pubmed/28660226 http://dx.doi.org/10.22038/aojnmb.2017.8702 |
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