Engineering CAR-T cells

Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T c...

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Detalles Bibliográficos
Autores principales: Zhang, Cheng, Liu, Jun, Zhong, Jiang F., Zhang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482931/
https://www.ncbi.nlm.nih.gov/pubmed/28652918
http://dx.doi.org/10.1186/s40364-017-0102-y
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author Zhang, Cheng
Liu, Jun
Zhong, Jiang F.
Zhang, Xi
author_facet Zhang, Cheng
Liu, Jun
Zhong, Jiang F.
Zhang, Xi
author_sort Zhang, Cheng
collection PubMed
description Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.
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spelling pubmed-54829312017-06-26 Engineering CAR-T cells Zhang, Cheng Liu, Jun Zhong, Jiang F. Zhang, Xi Biomark Res Review Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells. BioMed Central 2017-06-24 /pmc/articles/PMC5482931/ /pubmed/28652918 http://dx.doi.org/10.1186/s40364-017-0102-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhang, Cheng
Liu, Jun
Zhong, Jiang F.
Zhang, Xi
Engineering CAR-T cells
title Engineering CAR-T cells
title_full Engineering CAR-T cells
title_fullStr Engineering CAR-T cells
title_full_unstemmed Engineering CAR-T cells
title_short Engineering CAR-T cells
title_sort engineering car-t cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482931/
https://www.ncbi.nlm.nih.gov/pubmed/28652918
http://dx.doi.org/10.1186/s40364-017-0102-y
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