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Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes
In recent years, phenotypic-based screens have become increasingly popular in drug discovery. A major challenge of this approach is that it does not provide information about the mechanism of action of the hits. This has led to the development of multiple strategies for target deconvolution. Thermal...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482948/ https://www.ncbi.nlm.nih.gov/pubmed/28652855 http://dx.doi.org/10.1186/s12953-017-0122-4 |