The myths surrounding mild stimulation in vitro fertilization (IVF)

So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction...

Descripción completa

Detalles Bibliográficos
Autores principales: Orvieto, Raoul, Vanni, Valeria Stella, Gleicher, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482955/
https://www.ncbi.nlm.nih.gov/pubmed/28645286
http://dx.doi.org/10.1186/s12958-017-0266-1
_version_ 1783245665119240192
author Orvieto, Raoul
Vanni, Valeria Stella
Gleicher, Norbert
author_facet Orvieto, Raoul
Vanni, Valeria Stella
Gleicher, Norbert
author_sort Orvieto, Raoul
collection PubMed
description So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.
format Online
Article
Text
id pubmed-5482955
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54829552017-06-26 The myths surrounding mild stimulation in vitro fertilization (IVF) Orvieto, Raoul Vanni, Valeria Stella Gleicher, Norbert Reprod Biol Endocrinol Review So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction. BioMed Central 2017-06-24 /pmc/articles/PMC5482955/ /pubmed/28645286 http://dx.doi.org/10.1186/s12958-017-0266-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Orvieto, Raoul
Vanni, Valeria Stella
Gleicher, Norbert
The myths surrounding mild stimulation in vitro fertilization (IVF)
title The myths surrounding mild stimulation in vitro fertilization (IVF)
title_full The myths surrounding mild stimulation in vitro fertilization (IVF)
title_fullStr The myths surrounding mild stimulation in vitro fertilization (IVF)
title_full_unstemmed The myths surrounding mild stimulation in vitro fertilization (IVF)
title_short The myths surrounding mild stimulation in vitro fertilization (IVF)
title_sort myths surrounding mild stimulation in vitro fertilization (ivf)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482955/
https://www.ncbi.nlm.nih.gov/pubmed/28645286
http://dx.doi.org/10.1186/s12958-017-0266-1
work_keys_str_mv AT orvietoraoul themythssurroundingmildstimulationinvitrofertilizationivf
AT vannivaleriastella themythssurroundingmildstimulationinvitrofertilizationivf
AT gleichernorbert themythssurroundingmildstimulationinvitrofertilizationivf
AT orvietoraoul mythssurroundingmildstimulationinvitrofertilizationivf
AT vannivaleriastella mythssurroundingmildstimulationinvitrofertilizationivf
AT gleichernorbert mythssurroundingmildstimulationinvitrofertilizationivf

Ejemplares similares