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The role of nitric oxide during embryonic epidermis development of Xenopus laevis
Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downs...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483018/ https://www.ncbi.nlm.nih.gov/pubmed/28483981 http://dx.doi.org/10.1242/bio.023739 |
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author | Tomankova, Silvie Abaffy, Pavel Sindelka, Radek |
author_facet | Tomankova, Silvie Abaffy, Pavel Sindelka, Radek |
author_sort | Tomankova, Silvie |
collection | PubMed |
description | Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development. |
format | Online Article Text |
id | pubmed-5483018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54830182017-06-28 The role of nitric oxide during embryonic epidermis development of Xenopus laevis Tomankova, Silvie Abaffy, Pavel Sindelka, Radek Biol Open Research Article Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development. The Company of Biologists Ltd 2017-05-08 /pmc/articles/PMC5483018/ /pubmed/28483981 http://dx.doi.org/10.1242/bio.023739 Text en © 2017. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Tomankova, Silvie Abaffy, Pavel Sindelka, Radek The role of nitric oxide during embryonic epidermis development of Xenopus laevis |
title | The role of nitric oxide during embryonic epidermis development of Xenopus laevis |
title_full | The role of nitric oxide during embryonic epidermis development of Xenopus laevis |
title_fullStr | The role of nitric oxide during embryonic epidermis development of Xenopus laevis |
title_full_unstemmed | The role of nitric oxide during embryonic epidermis development of Xenopus laevis |
title_short | The role of nitric oxide during embryonic epidermis development of Xenopus laevis |
title_sort | role of nitric oxide during embryonic epidermis development of xenopus laevis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483018/ https://www.ncbi.nlm.nih.gov/pubmed/28483981 http://dx.doi.org/10.1242/bio.023739 |
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