MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown mechanisms. Recently, we identified Midkine as...

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Detalles Bibliográficos
Autores principales: Khan, Niamat, Binder, Lutz, Pantakani, D. V. Krishna, Asif, Abdul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483464/
https://www.ncbi.nlm.nih.gov/pubmed/28694783
http://dx.doi.org/10.3389/fphys.2017.00438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483464/
https://www.ncbi.nlm.nih.gov/pubmed/28694783
http://dx.doi.org/10.3389/fphys.2017.00438

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