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Advances in surgical management for locally recurrent rectal cancer: How far have we come?

Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and the...

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Autores principales: Lee, Daniel Jin-Keat, Sagar, Peter M, Sadadcharam, Gaitri, Tan, Kok-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483491/
https://www.ncbi.nlm.nih.gov/pubmed/28694657
http://dx.doi.org/10.3748/wjg.v23.i23.4170
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author Lee, Daniel Jin-Keat
Sagar, Peter M
Sadadcharam, Gaitri
Tan, Kok-Yang
author_facet Lee, Daniel Jin-Keat
Sagar, Peter M
Sadadcharam, Gaitri
Tan, Kok-Yang
author_sort Lee, Daniel Jin-Keat
collection PubMed
description Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it.
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spelling pubmed-54834912017-07-10 Advances in surgical management for locally recurrent rectal cancer: How far have we come? Lee, Daniel Jin-Keat Sagar, Peter M Sadadcharam, Gaitri Tan, Kok-Yang World J Gastroenterol Minireviews Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it. Baishideng Publishing Group Inc 2017-06-21 2017-06-21 /pmc/articles/PMC5483491/ /pubmed/28694657 http://dx.doi.org/10.3748/wjg.v23.i23.4170 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Lee, Daniel Jin-Keat
Sagar, Peter M
Sadadcharam, Gaitri
Tan, Kok-Yang
Advances in surgical management for locally recurrent rectal cancer: How far have we come?
title Advances in surgical management for locally recurrent rectal cancer: How far have we come?
title_full Advances in surgical management for locally recurrent rectal cancer: How far have we come?
title_fullStr Advances in surgical management for locally recurrent rectal cancer: How far have we come?
title_full_unstemmed Advances in surgical management for locally recurrent rectal cancer: How far have we come?
title_short Advances in surgical management for locally recurrent rectal cancer: How far have we come?
title_sort advances in surgical management for locally recurrent rectal cancer: how far have we come?
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483491/
https://www.ncbi.nlm.nih.gov/pubmed/28694657
http://dx.doi.org/10.3748/wjg.v23.i23.4170
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