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Advances in surgical management for locally recurrent rectal cancer: How far have we come?
Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483491/ https://www.ncbi.nlm.nih.gov/pubmed/28694657 http://dx.doi.org/10.3748/wjg.v23.i23.4170 |
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author | Lee, Daniel Jin-Keat Sagar, Peter M Sadadcharam, Gaitri Tan, Kok-Yang |
author_facet | Lee, Daniel Jin-Keat Sagar, Peter M Sadadcharam, Gaitri Tan, Kok-Yang |
author_sort | Lee, Daniel Jin-Keat |
collection | PubMed |
description | Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it. |
format | Online Article Text |
id | pubmed-5483491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-54834912017-07-10 Advances in surgical management for locally recurrent rectal cancer: How far have we come? Lee, Daniel Jin-Keat Sagar, Peter M Sadadcharam, Gaitri Tan, Kok-Yang World J Gastroenterol Minireviews Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it. Baishideng Publishing Group Inc 2017-06-21 2017-06-21 /pmc/articles/PMC5483491/ /pubmed/28694657 http://dx.doi.org/10.3748/wjg.v23.i23.4170 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Lee, Daniel Jin-Keat Sagar, Peter M Sadadcharam, Gaitri Tan, Kok-Yang Advances in surgical management for locally recurrent rectal cancer: How far have we come? |
title | Advances in surgical management for locally recurrent rectal cancer: How far have we come? |
title_full | Advances in surgical management for locally recurrent rectal cancer: How far have we come? |
title_fullStr | Advances in surgical management for locally recurrent rectal cancer: How far have we come? |
title_full_unstemmed | Advances in surgical management for locally recurrent rectal cancer: How far have we come? |
title_short | Advances in surgical management for locally recurrent rectal cancer: How far have we come? |
title_sort | advances in surgical management for locally recurrent rectal cancer: how far have we come? |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483491/ https://www.ncbi.nlm.nih.gov/pubmed/28694657 http://dx.doi.org/10.3748/wjg.v23.i23.4170 |
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