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Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature

Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, which accounts for 1–2% of adult cancers worldwide. Despite quite a few reports on traumatic events followed by STS formation, the link between the two events remains a point of controversy. In this paper, we present the case of a youn...

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Detalles Bibliográficos
Autores principales: Bar, Yael, Merimsky, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483586/
https://www.ncbi.nlm.nih.gov/pubmed/28695109
http://dx.doi.org/10.3389/fonc.2017.00134
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author Bar, Yael
Merimsky, Ofer
author_facet Bar, Yael
Merimsky, Ofer
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description Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, which accounts for 1–2% of adult cancers worldwide. Despite quite a few reports on traumatic events followed by STS formation, the link between the two events remains a point of controversy. In this paper, we present the case of a young patient who had a rhabdomyosarcoma in the lower extremity, which had developed in the same location where the patient was wounded by a gunshot 9 years earlier. X-ray and CT scans clearly showed metal fragments in the area of sarcoma formation. The patient underwent neoadjuvant chemotherapy treatment, to which the tumor was, unfortunately, unresponsive. Therefore, the patient was referred to below-knee amputation of the injured leg. There are several possible etiological factors for sarcoma development in this patient, including tissue damage and inflammation, as well as the presence of metal fragments in the tissue and the limb’s exposure to radiation during multiple imaging tests. Here, we will discuss the potential influence wielded by the injury itself, as well as its complications and its medical management on the formation of the sarcoma, in light of the current literature.
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spelling pubmed-54835862017-07-10 Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature Bar, Yael Merimsky, Ofer Front Oncol Oncology Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, which accounts for 1–2% of adult cancers worldwide. Despite quite a few reports on traumatic events followed by STS formation, the link between the two events remains a point of controversy. In this paper, we present the case of a young patient who had a rhabdomyosarcoma in the lower extremity, which had developed in the same location where the patient was wounded by a gunshot 9 years earlier. X-ray and CT scans clearly showed metal fragments in the area of sarcoma formation. The patient underwent neoadjuvant chemotherapy treatment, to which the tumor was, unfortunately, unresponsive. Therefore, the patient was referred to below-knee amputation of the injured leg. There are several possible etiological factors for sarcoma development in this patient, including tissue damage and inflammation, as well as the presence of metal fragments in the tissue and the limb’s exposure to radiation during multiple imaging tests. Here, we will discuss the potential influence wielded by the injury itself, as well as its complications and its medical management on the formation of the sarcoma, in light of the current literature. Frontiers Media S.A. 2017-06-26 /pmc/articles/PMC5483586/ /pubmed/28695109 http://dx.doi.org/10.3389/fonc.2017.00134 Text en Copyright © 2017 Bar and Merimsky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bar, Yael
Merimsky, Ofer
Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
title Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
title_full Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
title_fullStr Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
title_full_unstemmed Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
title_short Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
title_sort soft-tissue sarcoma following traumatic injury: case report and review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483586/
https://www.ncbi.nlm.nih.gov/pubmed/28695109
http://dx.doi.org/10.3389/fonc.2017.00134
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