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Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature
Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, which accounts for 1–2% of adult cancers worldwide. Despite quite a few reports on traumatic events followed by STS formation, the link between the two events remains a point of controversy. In this paper, we present the case of a youn...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483586/ https://www.ncbi.nlm.nih.gov/pubmed/28695109 http://dx.doi.org/10.3389/fonc.2017.00134 |
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author | Bar, Yael Merimsky, Ofer |
author_facet | Bar, Yael Merimsky, Ofer |
author_sort | Bar, Yael |
collection | PubMed |
description | Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, which accounts for 1–2% of adult cancers worldwide. Despite quite a few reports on traumatic events followed by STS formation, the link between the two events remains a point of controversy. In this paper, we present the case of a young patient who had a rhabdomyosarcoma in the lower extremity, which had developed in the same location where the patient was wounded by a gunshot 9 years earlier. X-ray and CT scans clearly showed metal fragments in the area of sarcoma formation. The patient underwent neoadjuvant chemotherapy treatment, to which the tumor was, unfortunately, unresponsive. Therefore, the patient was referred to below-knee amputation of the injured leg. There are several possible etiological factors for sarcoma development in this patient, including tissue damage and inflammation, as well as the presence of metal fragments in the tissue and the limb’s exposure to radiation during multiple imaging tests. Here, we will discuss the potential influence wielded by the injury itself, as well as its complications and its medical management on the formation of the sarcoma, in light of the current literature. |
format | Online Article Text |
id | pubmed-5483586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54835862017-07-10 Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature Bar, Yael Merimsky, Ofer Front Oncol Oncology Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, which accounts for 1–2% of adult cancers worldwide. Despite quite a few reports on traumatic events followed by STS formation, the link between the two events remains a point of controversy. In this paper, we present the case of a young patient who had a rhabdomyosarcoma in the lower extremity, which had developed in the same location where the patient was wounded by a gunshot 9 years earlier. X-ray and CT scans clearly showed metal fragments in the area of sarcoma formation. The patient underwent neoadjuvant chemotherapy treatment, to which the tumor was, unfortunately, unresponsive. Therefore, the patient was referred to below-knee amputation of the injured leg. There are several possible etiological factors for sarcoma development in this patient, including tissue damage and inflammation, as well as the presence of metal fragments in the tissue and the limb’s exposure to radiation during multiple imaging tests. Here, we will discuss the potential influence wielded by the injury itself, as well as its complications and its medical management on the formation of the sarcoma, in light of the current literature. Frontiers Media S.A. 2017-06-26 /pmc/articles/PMC5483586/ /pubmed/28695109 http://dx.doi.org/10.3389/fonc.2017.00134 Text en Copyright © 2017 Bar and Merimsky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Bar, Yael Merimsky, Ofer Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature |
title | Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature |
title_full | Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature |
title_fullStr | Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature |
title_full_unstemmed | Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature |
title_short | Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature |
title_sort | soft-tissue sarcoma following traumatic injury: case report and review of the literature |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483586/ https://www.ncbi.nlm.nih.gov/pubmed/28695109 http://dx.doi.org/10.3389/fonc.2017.00134 |
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