HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

HIV-1 replication can be efficiently inhibited by intracellular expression of an siRNA targeting the viral RNA. However, HIV-1 escape variants emerged after prolonged culturing. These RNAi-resistant viruses contain nucleotide substitutions or deletions in or near the targeted sequence. We observed a...

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Detalles Bibliográficos
Autores principales: Westerhout, Ellen M., Ooms, Marcel, Vink, Monique, Das, Atze T., Berkhout, Ben
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548362/
https://www.ncbi.nlm.nih.gov/pubmed/15687388
http://dx.doi.org/10.1093/nar/gki220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548362/
https://www.ncbi.nlm.nih.gov/pubmed/15687388
http://dx.doi.org/10.1093/nar/gki220

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