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HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

HIV-1 replication can be efficiently inhibited by intracellular expression of an siRNA targeting the viral RNA. However, HIV-1 escape variants emerged after prolonged culturing. These RNAi-resistant viruses contain nucleotide substitutions or deletions in or near the targeted sequence. We observed a...

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Detalles Bibliográficos
Autores principales:	Westerhout, Ellen M., Ooms, Marcel, Vink, Monique, Das, Atze T., Berkhout, Ben
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548362/ https://www.ncbi.nlm.nih.gov/pubmed/15687388 http://dx.doi.org/10.1093/nar/gki220

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