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Neuropsychiatric Burden in Huntington’s Disease

Huntington’s disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients’ autonomy and quality of life, also impacting patients’ social life. It is estimated that a p...

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Autores principales: Paoli, Ricardo Augusto, Botturi, Andrea, Ciammola, Andrea, Silani, Vincenzo, Prunas, Cecilia, Lucchiari, Claudio, Zugno, Elisa, Caletti, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483640/
https://www.ncbi.nlm.nih.gov/pubmed/28621715
http://dx.doi.org/10.3390/brainsci7060067
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author Paoli, Ricardo Augusto
Botturi, Andrea
Ciammola, Andrea
Silani, Vincenzo
Prunas, Cecilia
Lucchiari, Claudio
Zugno, Elisa
Caletti, Elisabetta
author_facet Paoli, Ricardo Augusto
Botturi, Andrea
Ciammola, Andrea
Silani, Vincenzo
Prunas, Cecilia
Lucchiari, Claudio
Zugno, Elisa
Caletti, Elisabetta
author_sort Paoli, Ricardo Augusto
collection PubMed
description Huntington’s disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients’ autonomy and quality of life, also impacting patients’ social life. It is estimated that a prevalence between 33% and 76% of the main psychiatric syndromes may arise in different phases of the disease, often in atypical form, even 20 years before the onset of chorea and dementia. We present a narrative review of the literature describing the main psychopathological patterns that may be found in Huntington’s disease, searching for a related article in the main database sources (Medline, ISI Web of Knowledge, Scopus, and Medscape). Psychiatric conditions were classified into two main categories: affective and nonaffective disorders/symptoms; and anxiety and neuropsychiatric features such as apathy and irritability. Though the literature is extensive, it is not always convergent, probably due to the high heterogeneity of methods used. We summarize main papers for pathology and sample size, in order to present a synoptic vision of the argument. Since the association between Huntington’s disease and psychiatric symptoms was demonstrated, we argue that the prevalent and more invalidating psychiatric components should be recognized as early as possible during the disease course in order to best address psychopharmacological therapy, improve quality of life, and also reduce burden on caregivers.
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spelling pubmed-54836402017-06-28 Neuropsychiatric Burden in Huntington’s Disease Paoli, Ricardo Augusto Botturi, Andrea Ciammola, Andrea Silani, Vincenzo Prunas, Cecilia Lucchiari, Claudio Zugno, Elisa Caletti, Elisabetta Brain Sci Review Huntington’s disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients’ autonomy and quality of life, also impacting patients’ social life. It is estimated that a prevalence between 33% and 76% of the main psychiatric syndromes may arise in different phases of the disease, often in atypical form, even 20 years before the onset of chorea and dementia. We present a narrative review of the literature describing the main psychopathological patterns that may be found in Huntington’s disease, searching for a related article in the main database sources (Medline, ISI Web of Knowledge, Scopus, and Medscape). Psychiatric conditions were classified into two main categories: affective and nonaffective disorders/symptoms; and anxiety and neuropsychiatric features such as apathy and irritability. Though the literature is extensive, it is not always convergent, probably due to the high heterogeneity of methods used. We summarize main papers for pathology and sample size, in order to present a synoptic vision of the argument. Since the association between Huntington’s disease and psychiatric symptoms was demonstrated, we argue that the prevalent and more invalidating psychiatric components should be recognized as early as possible during the disease course in order to best address psychopharmacological therapy, improve quality of life, and also reduce burden on caregivers. MDPI 2017-06-16 /pmc/articles/PMC5483640/ /pubmed/28621715 http://dx.doi.org/10.3390/brainsci7060067 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paoli, Ricardo Augusto
Botturi, Andrea
Ciammola, Andrea
Silani, Vincenzo
Prunas, Cecilia
Lucchiari, Claudio
Zugno, Elisa
Caletti, Elisabetta
Neuropsychiatric Burden in Huntington’s Disease
title Neuropsychiatric Burden in Huntington’s Disease
title_full Neuropsychiatric Burden in Huntington’s Disease
title_fullStr Neuropsychiatric Burden in Huntington’s Disease
title_full_unstemmed Neuropsychiatric Burden in Huntington’s Disease
title_short Neuropsychiatric Burden in Huntington’s Disease
title_sort neuropsychiatric burden in huntington’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483640/
https://www.ncbi.nlm.nih.gov/pubmed/28621715
http://dx.doi.org/10.3390/brainsci7060067
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