Cargando…
Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort
BACKGROUND: To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG). METHOD: Polymorphism rs547984 was genotyped using Taq-Man® assay in 185 subjects compr...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483842/ https://www.ncbi.nlm.nih.gov/pubmed/28648143 http://dx.doi.org/10.1186/s12952-017-0077-0 |
_version_ | 1783245792165756928 |
---|---|
author | Azad, Taif A. Edward, Nikhil B. Kondkar, Altaf A. Kalantan, Hatem Altuwaijri, Saleh Sultan, Tahira Al-Mobarak, Faisal A. Al-Obeidan, Saleh A. Abu-Amero, Khaled K. |
author_facet | Azad, Taif A. Edward, Nikhil B. Kondkar, Altaf A. Kalantan, Hatem Altuwaijri, Saleh Sultan, Tahira Al-Mobarak, Faisal A. Al-Obeidan, Saleh A. Abu-Amero, Khaled K. |
author_sort | Azad, Taif A. |
collection | PubMed |
description | BACKGROUND: To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG). METHOD: Polymorphism rs547984 was genotyped using Taq-Man® assay in 185 subjects comprising of 90 unrelated POAG cases and 95 controls of Saudi origin. RESULTS: Association analysis between cases and controls revealed no significant genotype distribution under additive (p = 0.356), dominant (p = 0.517) and recessive (p = 0.309) models. Besides, the allele frequency distribution was also found to be non-significant (p = 0.70). The minor “A” allele frequency was found to be 0.49 and 0.50 among POAG cases and controls, respectively. In addition, specific clinical indices used to assess severity of glaucoma such as intraocular pressure (IOP), cup/disc ratio and number of anti-glaucoma medication also did not show any significant genotype distribution in POAG cases. CONCLUSION: Polymorphism rs547984 is neither associated with any clinical indices important for POAG such as IOP and cup/disc ratio nor is a risk factor for POAG in the Saudi cohort. |
format | Online Article Text |
id | pubmed-5483842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54838422017-06-26 Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort Azad, Taif A. Edward, Nikhil B. Kondkar, Altaf A. Kalantan, Hatem Altuwaijri, Saleh Sultan, Tahira Al-Mobarak, Faisal A. Al-Obeidan, Saleh A. Abu-Amero, Khaled K. J Negat Results Biomed Research BACKGROUND: To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG). METHOD: Polymorphism rs547984 was genotyped using Taq-Man® assay in 185 subjects comprising of 90 unrelated POAG cases and 95 controls of Saudi origin. RESULTS: Association analysis between cases and controls revealed no significant genotype distribution under additive (p = 0.356), dominant (p = 0.517) and recessive (p = 0.309) models. Besides, the allele frequency distribution was also found to be non-significant (p = 0.70). The minor “A” allele frequency was found to be 0.49 and 0.50 among POAG cases and controls, respectively. In addition, specific clinical indices used to assess severity of glaucoma such as intraocular pressure (IOP), cup/disc ratio and number of anti-glaucoma medication also did not show any significant genotype distribution in POAG cases. CONCLUSION: Polymorphism rs547984 is neither associated with any clinical indices important for POAG such as IOP and cup/disc ratio nor is a risk factor for POAG in the Saudi cohort. BioMed Central 2017-06-26 /pmc/articles/PMC5483842/ /pubmed/28648143 http://dx.doi.org/10.1186/s12952-017-0077-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Azad, Taif A. Edward, Nikhil B. Kondkar, Altaf A. Kalantan, Hatem Altuwaijri, Saleh Sultan, Tahira Al-Mobarak, Faisal A. Al-Obeidan, Saleh A. Abu-Amero, Khaled K. Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort |
title | Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort |
title_full | Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort |
title_fullStr | Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort |
title_full_unstemmed | Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort |
title_short | Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort |
title_sort | polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a saudi cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483842/ https://www.ncbi.nlm.nih.gov/pubmed/28648143 http://dx.doi.org/10.1186/s12952-017-0077-0 |
work_keys_str_mv | AT azadtaifa polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT edwardnikhilb polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT kondkaraltafa polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT kalantanhatem polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT altuwaijrisaleh polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT sultantahira polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT almobarakfaisala polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT alobeidansaleha polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort AT abuamerokhaledk polymorphismrs547984onhumanchromosome1q43isnotassociatedwithprimaryopenangleglaucomainasaudicohort |