SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors

RNA binding proteins and signaling components control the production of pro-death and pro-survival splice variants of Bcl-x. DNA damage promoted by oxaliplatin increases the level of pro-apoptotic Bcl-xS in an ATM/CHK2-dependent manner, but how this shift is enforced is not known. Here, we show that...

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Detalles Bibliográficos
Autores principales: Shkreta, Lulzim, Toutant, Johanne, Durand, Mathieu, Manley, James L., Chabot, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483951/
https://www.ncbi.nlm.nih.gov/pubmed/27851963
http://dx.doi.org/10.1016/j.celrep.2016.10.071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483951/
https://www.ncbi.nlm.nih.gov/pubmed/27851963
http://dx.doi.org/10.1016/j.celrep.2016.10.071

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