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Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease
The present study was designed to investigate the role of circulating miRNA-21 (miR-21) in vascular restenosis of lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. A total of 412 LEAOD patients were enrolled randomly in the present study. According to computed...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484015/ https://www.ncbi.nlm.nih.gov/pubmed/28250135 http://dx.doi.org/10.1042/BSR20160502 |
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author | Zhang, Bo Yao, Ye Sun, Qing-Feng Liu, Si-qi Jing, Bao Yuan, Chao Liu, Xin-Yu Jiao, Tong Li, Hao-cheng Wang, Hai-Yang |
author_facet | Zhang, Bo Yao, Ye Sun, Qing-Feng Liu, Si-qi Jing, Bao Yuan, Chao Liu, Xin-Yu Jiao, Tong Li, Hao-cheng Wang, Hai-Yang |
author_sort | Zhang, Bo |
collection | PubMed |
description | The present study was designed to investigate the role of circulating miRNA-21 (miR-21) in vascular restenosis of lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. A total of 412 LEAOD patients were enrolled randomly in the present study. According to computed tomography angiography (CTA) and ankle-brachial index (ABI), patients were assigned into the restenosis group and the non-restenosis group. miR-21 expression was detected with quantitative real-time PCR (qRT-PCR) before and after patients underwent interventional therapy. A follow-up period of 6 months was achieved. A receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC) was calculated to assess the predictive value of miR-21 in vascular restenosis. Patients were older in the restenosis group than in the non-restenosis group. The percentages of patients with diabetes and hypertension were higher in the restenosis group than in the non-restenosis group, and the Fontaine stage exhibited a significant difference between the two groups. miR-21 expression was higher in the restenosis group than in the non-restenosis group. miR-21 expression level was related to age, diabetes and hypertension in the restenosis group. Using miR-21 to predict vascular restenosis yielded an AUC of 0.938 (95% confidence interval (CI): 0.898–0.977), with Youden index of 0.817, sensitivity of 83.5% and specificity of 98.2%. Logistic regression analysis revealed that diabetes and miR-21 expression were the major risk factors for vascular restenosis of LEAOD. miR-21 can be used as a predictive indicator for vascular restenosis of LEAOD after interventional therapy. |
format | Online Article Text |
id | pubmed-5484015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54840152017-07-06 Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease Zhang, Bo Yao, Ye Sun, Qing-Feng Liu, Si-qi Jing, Bao Yuan, Chao Liu, Xin-Yu Jiao, Tong Li, Hao-cheng Wang, Hai-Yang Biosci Rep Research Articles The present study was designed to investigate the role of circulating miRNA-21 (miR-21) in vascular restenosis of lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. A total of 412 LEAOD patients were enrolled randomly in the present study. According to computed tomography angiography (CTA) and ankle-brachial index (ABI), patients were assigned into the restenosis group and the non-restenosis group. miR-21 expression was detected with quantitative real-time PCR (qRT-PCR) before and after patients underwent interventional therapy. A follow-up period of 6 months was achieved. A receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC) was calculated to assess the predictive value of miR-21 in vascular restenosis. Patients were older in the restenosis group than in the non-restenosis group. The percentages of patients with diabetes and hypertension were higher in the restenosis group than in the non-restenosis group, and the Fontaine stage exhibited a significant difference between the two groups. miR-21 expression was higher in the restenosis group than in the non-restenosis group. miR-21 expression level was related to age, diabetes and hypertension in the restenosis group. Using miR-21 to predict vascular restenosis yielded an AUC of 0.938 (95% confidence interval (CI): 0.898–0.977), with Youden index of 0.817, sensitivity of 83.5% and specificity of 98.2%. Logistic regression analysis revealed that diabetes and miR-21 expression were the major risk factors for vascular restenosis of LEAOD. miR-21 can be used as a predictive indicator for vascular restenosis of LEAOD after interventional therapy. Portland Press Ltd. 2017-04-20 /pmc/articles/PMC5484015/ /pubmed/28250135 http://dx.doi.org/10.1042/BSR20160502 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Zhang, Bo Yao, Ye Sun, Qing-Feng Liu, Si-qi Jing, Bao Yuan, Chao Liu, Xin-Yu Jiao, Tong Li, Hao-cheng Wang, Hai-Yang Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease |
title | Circulating mircoRNA-21 as a predictor for vascular restenosis after
interventional therapy in patients with lower extremity arterial occlusive
disease |
title_full | Circulating mircoRNA-21 as a predictor for vascular restenosis after
interventional therapy in patients with lower extremity arterial occlusive
disease |
title_fullStr | Circulating mircoRNA-21 as a predictor for vascular restenosis after
interventional therapy in patients with lower extremity arterial occlusive
disease |
title_full_unstemmed | Circulating mircoRNA-21 as a predictor for vascular restenosis after
interventional therapy in patients with lower extremity arterial occlusive
disease |
title_short | Circulating mircoRNA-21 as a predictor for vascular restenosis after
interventional therapy in patients with lower extremity arterial occlusive
disease |
title_sort | circulating mircorna-21 as a predictor for vascular restenosis after
interventional therapy in patients with lower extremity arterial occlusive
disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484015/ https://www.ncbi.nlm.nih.gov/pubmed/28250135 http://dx.doi.org/10.1042/BSR20160502 |
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