Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis

The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane...

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Detalles Bibliográficos
Autores principales: Campbell, Sanjay, Murray, JeAnn, Delgoda, Rupika, Gallimore, Winklet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484100/
https://www.ncbi.nlm.nih.gov/pubmed/28556792
http://dx.doi.org/10.3390/md15060150
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author Campbell, Sanjay
Murray, JeAnn
Delgoda, Rupika
Gallimore, Winklet
author_facet Campbell, Sanjay
Murray, JeAnn
Delgoda, Rupika
Gallimore, Winklet
author_sort Campbell, Sanjay
collection PubMed
description The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1–3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (1–3) displayed moderate, concentration dependent, cytotoxicity.
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spelling pubmed-54841002017-06-29 Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis Campbell, Sanjay Murray, JeAnn Delgoda, Rupika Gallimore, Winklet Mar Drugs Article The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1–3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (1–3) displayed moderate, concentration dependent, cytotoxicity. MDPI 2017-05-30 /pmc/articles/PMC5484100/ /pubmed/28556792 http://dx.doi.org/10.3390/md15060150 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campbell, Sanjay
Murray, JeAnn
Delgoda, Rupika
Gallimore, Winklet
Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
title Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
title_full Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
title_fullStr Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
title_full_unstemmed Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
title_short Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
title_sort two new oxodolastane diterpenes from the jamaican macroalga canistrocarpus cervicornis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484100/
https://www.ncbi.nlm.nih.gov/pubmed/28556792
http://dx.doi.org/10.3390/md15060150
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