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Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities

Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities agains...

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Autores principales: Jiang, Shutai, Zhang, Lili, Pei, Xuechang, Deng, Fang, Hu, Dan, Chen, Guodong, Wang, Chuanxi, Hong, Kui, Yao, Xinsheng, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484103/
https://www.ncbi.nlm.nih.gov/pubmed/28555051
http://dx.doi.org/10.3390/md15060153
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author Jiang, Shutai
Zhang, Lili
Pei, Xuechang
Deng, Fang
Hu, Dan
Chen, Guodong
Wang, Chuanxi
Hong, Kui
Yao, Xinsheng
Gao, Hao
author_facet Jiang, Shutai
Zhang, Lili
Pei, Xuechang
Deng, Fang
Hu, Dan
Chen, Guodong
Wang, Chuanxi
Hong, Kui
Yao, Xinsheng
Gao, Hao
author_sort Jiang, Shutai
collection PubMed
description Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger of 1–3 were evaluated. Compounds 1–2 exhibited activities against S. aureus with minimal inhibitory concentrations (MICs) of 32 µg/mL and 4 µg/mL, respectively. The fact that 1–2 showed stronger activity against S. aureus 209P than 3 indicated that the epoxy unit was important for antimicrobial activity. This structure–activity tendency of chalcomycins against S. aureus is different from that of aldgamycins reported in our previous research, which provide a valuable example for the phenomenon that 16-membered macrolides with different sugars do not have parallel structure–activity relationships.
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spelling pubmed-54841032017-06-29 Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities Jiang, Shutai Zhang, Lili Pei, Xuechang Deng, Fang Hu, Dan Chen, Guodong Wang, Chuanxi Hong, Kui Yao, Xinsheng Gao, Hao Mar Drugs Communication Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger of 1–3 were evaluated. Compounds 1–2 exhibited activities against S. aureus with minimal inhibitory concentrations (MICs) of 32 µg/mL and 4 µg/mL, respectively. The fact that 1–2 showed stronger activity against S. aureus 209P than 3 indicated that the epoxy unit was important for antimicrobial activity. This structure–activity tendency of chalcomycins against S. aureus is different from that of aldgamycins reported in our previous research, which provide a valuable example for the phenomenon that 16-membered macrolides with different sugars do not have parallel structure–activity relationships. MDPI 2017-05-29 /pmc/articles/PMC5484103/ /pubmed/28555051 http://dx.doi.org/10.3390/md15060153 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Jiang, Shutai
Zhang, Lili
Pei, Xuechang
Deng, Fang
Hu, Dan
Chen, Guodong
Wang, Chuanxi
Hong, Kui
Yao, Xinsheng
Gao, Hao
Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
title Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
title_full Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
title_fullStr Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
title_full_unstemmed Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
title_short Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
title_sort chalcomycins from marine-derived streptomyces sp. and their antimicrobial activities
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484103/
https://www.ncbi.nlm.nih.gov/pubmed/28555051
http://dx.doi.org/10.3390/md15060153
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