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Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities
Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities agains...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484103/ https://www.ncbi.nlm.nih.gov/pubmed/28555051 http://dx.doi.org/10.3390/md15060153 |
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author | Jiang, Shutai Zhang, Lili Pei, Xuechang Deng, Fang Hu, Dan Chen, Guodong Wang, Chuanxi Hong, Kui Yao, Xinsheng Gao, Hao |
author_facet | Jiang, Shutai Zhang, Lili Pei, Xuechang Deng, Fang Hu, Dan Chen, Guodong Wang, Chuanxi Hong, Kui Yao, Xinsheng Gao, Hao |
author_sort | Jiang, Shutai |
collection | PubMed |
description | Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger of 1–3 were evaluated. Compounds 1–2 exhibited activities against S. aureus with minimal inhibitory concentrations (MICs) of 32 µg/mL and 4 µg/mL, respectively. The fact that 1–2 showed stronger activity against S. aureus 209P than 3 indicated that the epoxy unit was important for antimicrobial activity. This structure–activity tendency of chalcomycins against S. aureus is different from that of aldgamycins reported in our previous research, which provide a valuable example for the phenomenon that 16-membered macrolides with different sugars do not have parallel structure–activity relationships. |
format | Online Article Text |
id | pubmed-5484103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54841032017-06-29 Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities Jiang, Shutai Zhang, Lili Pei, Xuechang Deng, Fang Hu, Dan Chen, Guodong Wang, Chuanxi Hong, Kui Yao, Xinsheng Gao, Hao Mar Drugs Communication Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger of 1–3 were evaluated. Compounds 1–2 exhibited activities against S. aureus with minimal inhibitory concentrations (MICs) of 32 µg/mL and 4 µg/mL, respectively. The fact that 1–2 showed stronger activity against S. aureus 209P than 3 indicated that the epoxy unit was important for antimicrobial activity. This structure–activity tendency of chalcomycins against S. aureus is different from that of aldgamycins reported in our previous research, which provide a valuable example for the phenomenon that 16-membered macrolides with different sugars do not have parallel structure–activity relationships. MDPI 2017-05-29 /pmc/articles/PMC5484103/ /pubmed/28555051 http://dx.doi.org/10.3390/md15060153 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Jiang, Shutai Zhang, Lili Pei, Xuechang Deng, Fang Hu, Dan Chen, Guodong Wang, Chuanxi Hong, Kui Yao, Xinsheng Gao, Hao Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities |
title | Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities |
title_full | Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities |
title_fullStr | Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities |
title_full_unstemmed | Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities |
title_short | Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities |
title_sort | chalcomycins from marine-derived streptomyces sp. and their antimicrobial activities |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484103/ https://www.ncbi.nlm.nih.gov/pubmed/28555051 http://dx.doi.org/10.3390/md15060153 |
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