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A Study of 11-[(3)H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats

Tetrodotoxin (TTX) is a powerful sodium channel blocker that in low doses can safely relieve severe pain. Studying the absorption, distribution, metabolism and excretion (ADME) of TTX is challenging given the extremely low lethal dose. We conducted radiolabeled ADME studies in Sprague-Dawley rats. A...

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Detalles Bibliográficos
Autores principales:	Hong, Bihong, Chen, Hui, Han, Jiacai, Xie, Quanling, He, Jianlin, Bai, Kaikai, Dong, Yanming, Yi, Ruizao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484109/ https://www.ncbi.nlm.nih.gov/pubmed/28574462 http://dx.doi.org/10.3390/md15060159

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