Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus

Trichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, M...

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Autores principales: Yamada, Takeshi, Suzue, Mayo, Arai, Takanobu, Kikuchi, Takashi, Tanaka, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484119/
https://www.ncbi.nlm.nih.gov/pubmed/28598397
http://dx.doi.org/10.3390/md15060169
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author Yamada, Takeshi
Suzue, Mayo
Arai, Takanobu
Kikuchi, Takashi
Tanaka, Reiko
author_facet Yamada, Takeshi
Suzue, Mayo
Arai, Takanobu
Kikuchi, Takashi
Tanaka, Reiko
author_sort Yamada, Takeshi
collection PubMed
description Trichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher’s method. In addition, 1 inhibited the growth of cancer cell lines potently.
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spelling pubmed-54841192017-06-29 Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus Yamada, Takeshi Suzue, Mayo Arai, Takanobu Kikuchi, Takashi Tanaka, Reiko Mar Drugs Article Trichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher’s method. In addition, 1 inhibited the growth of cancer cell lines potently. MDPI 2017-06-09 /pmc/articles/PMC5484119/ /pubmed/28598397 http://dx.doi.org/10.3390/md15060169 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yamada, Takeshi
Suzue, Mayo
Arai, Takanobu
Kikuchi, Takashi
Tanaka, Reiko
Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
title Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
title_full Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
title_fullStr Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
title_full_unstemmed Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
title_short Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
title_sort trichodermanins c–e, new diterpenes with a fused 6-5-6-6 ring system produced by a marine sponge-derived fungus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484119/
https://www.ncbi.nlm.nih.gov/pubmed/28598397
http://dx.doi.org/10.3390/md15060169
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