Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?

The role of Cdc45 in genomic duplication has remained unclear since its initial identification as an essential replication factor. Recent structural studies of Cdc45 and the evolutionarily-related archaeal GAN and bacterial RecJ nucleases have provided fresh insight into its function as co-activator...

Descripción completa

Detalles Bibliográficos
Autor principal: Pellegrini, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484177/
https://www.ncbi.nlm.nih.gov/pubmed/27919598
http://dx.doi.org/10.1016/j.bpc.2016.11.011
_version_ 1783245829703729152
author Pellegrini, Luca
author_facet Pellegrini, Luca
author_sort Pellegrini, Luca
collection PubMed
description The role of Cdc45 in genomic duplication has remained unclear since its initial identification as an essential replication factor. Recent structural studies of Cdc45 and the evolutionarily-related archaeal GAN and bacterial RecJ nucleases have provided fresh insight into its function as co-activator of the MCM helicase. The CMG helicase of the last archaeal/eukaryotic ancestor might have harboured a single-stranded DNA nuclease activity, conserved in some modern archaea.
format Online
Article
Text
id pubmed-5484177
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier Science B.V
record_format MEDLINE/PubMed
spelling pubmed-54841772017-07-10 Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome? Pellegrini, Luca Biophys Chem Article The role of Cdc45 in genomic duplication has remained unclear since its initial identification as an essential replication factor. Recent structural studies of Cdc45 and the evolutionarily-related archaeal GAN and bacterial RecJ nucleases have provided fresh insight into its function as co-activator of the MCM helicase. The CMG helicase of the last archaeal/eukaryotic ancestor might have harboured a single-stranded DNA nuclease activity, conserved in some modern archaea. Elsevier Science B.V 2017-06 /pmc/articles/PMC5484177/ /pubmed/27919598 http://dx.doi.org/10.1016/j.bpc.2016.11.011 Text en © 2016 The Author http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pellegrini, Luca
Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
title Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
title_full Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
title_fullStr Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
title_full_unstemmed Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
title_short Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
title_sort structural insights into cdc45 function: was there a nuclease at the heart of the ancestral replisome?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484177/
https://www.ncbi.nlm.nih.gov/pubmed/27919598
http://dx.doi.org/10.1016/j.bpc.2016.11.011
work_keys_str_mv AT pellegriniluca structuralinsightsintocdc45functionwasthereanucleaseattheheartoftheancestralreplisome

Ejemplares similares