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High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study

Hypertension and prehypertension can increase the risk of developing cardiovascular disease (CVD) and diabetes. However, whether the harmful effects of high blood pressure (BP) are also seen with high normotension remains unknown. This 10-year longitudinal follow-up study aimed to investigate the re...

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Autores principales: Chen, Yen-Lin, Hsu, Chun-Hsien, Hsieh, Chang-Hsun, Wu, Chung-Ze, Lin, Jiunn-Diann, Chang, Jin-Biou, Liang, Yao-Jen, Tsai, Yi-Ting, Hsia, Te-Lin, Pei, Dee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484226/
https://www.ncbi.nlm.nih.gov/pubmed/28640118
http://dx.doi.org/10.1097/MD.0000000000007227
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author Chen, Yen-Lin
Hsu, Chun-Hsien
Hsieh, Chang-Hsun
Wu, Chung-Ze
Lin, Jiunn-Diann
Chang, Jin-Biou
Liang, Yao-Jen
Tsai, Yi-Ting
Hsia, Te-Lin
Pei, Dee
author_facet Chen, Yen-Lin
Hsu, Chun-Hsien
Hsieh, Chang-Hsun
Wu, Chung-Ze
Lin, Jiunn-Diann
Chang, Jin-Biou
Liang, Yao-Jen
Tsai, Yi-Ting
Hsia, Te-Lin
Pei, Dee
author_sort Chen, Yen-Lin
collection PubMed
description Hypertension and prehypertension can increase the risk of developing cardiovascular disease (CVD) and diabetes. However, whether the harmful effects of high blood pressure (BP) are also seen with high normotension remains unknown. This 10-year longitudinal follow-up study aimed to investigate the relationships among normal-range BP, metabolic syndrome (MetS), and CVD. A total of 9133 nonmedicated normotensive participants, 4634 males and 4499 females, aged 60 years or older were enrolled in a standard health examination program at 2 academic hospitals and a health screening center in Taiwan. The study subjects were divided into 3 groups according to their BP. The systolic BP (SBP) ranges of groups 1, 2, and 3 were 91 to 100, 101 to 110, and 111 to 119 mmHg, whereas the diastolic BP (DBP) ranges of groups 1, 2, and 3 were 51 to 60, 61 to 70, and 71 to 79 mmHg, respectively. In the SBP3 group, both sexes had a higher odds ratio (OR) for having MetS or abnormal MetS components, except for triglycerides. Females in the DBP3 group had a higher OR for having MetS at baseline. After the follow-up period, the SBP3 group had a significantly higher hazard ratio (HR) for developing MetS. Males in the DBP3 group and females in the DBP2 and DBP3 groups had a significantly higher HR for developing MetS. Neither the SBP3 group nor the DBP3 group had a higher HR for developing nonfatal CVD. In the Kaplan-Meier analysis, SBP and DBP in both sexes showed statistical significance as predictors of MetS, but not of nonfatal CVD. High normotensive elderly individuals have an elevated risk of developing MetS at baseline and within 10 years of follow-up, but they are not at increased risk of CVD. Preventive interventions, such as life-style modification, should be offered early even to the apparently healthy elderly.
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spelling pubmed-54842262017-07-06 High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study Chen, Yen-Lin Hsu, Chun-Hsien Hsieh, Chang-Hsun Wu, Chung-Ze Lin, Jiunn-Diann Chang, Jin-Biou Liang, Yao-Jen Tsai, Yi-Ting Hsia, Te-Lin Pei, Dee Medicine (Baltimore) 4600 Hypertension and prehypertension can increase the risk of developing cardiovascular disease (CVD) and diabetes. However, whether the harmful effects of high blood pressure (BP) are also seen with high normotension remains unknown. This 10-year longitudinal follow-up study aimed to investigate the relationships among normal-range BP, metabolic syndrome (MetS), and CVD. A total of 9133 nonmedicated normotensive participants, 4634 males and 4499 females, aged 60 years or older were enrolled in a standard health examination program at 2 academic hospitals and a health screening center in Taiwan. The study subjects were divided into 3 groups according to their BP. The systolic BP (SBP) ranges of groups 1, 2, and 3 were 91 to 100, 101 to 110, and 111 to 119 mmHg, whereas the diastolic BP (DBP) ranges of groups 1, 2, and 3 were 51 to 60, 61 to 70, and 71 to 79 mmHg, respectively. In the SBP3 group, both sexes had a higher odds ratio (OR) for having MetS or abnormal MetS components, except for triglycerides. Females in the DBP3 group had a higher OR for having MetS at baseline. After the follow-up period, the SBP3 group had a significantly higher hazard ratio (HR) for developing MetS. Males in the DBP3 group and females in the DBP2 and DBP3 groups had a significantly higher HR for developing MetS. Neither the SBP3 group nor the DBP3 group had a higher HR for developing nonfatal CVD. In the Kaplan-Meier analysis, SBP and DBP in both sexes showed statistical significance as predictors of MetS, but not of nonfatal CVD. High normotensive elderly individuals have an elevated risk of developing MetS at baseline and within 10 years of follow-up, but they are not at increased risk of CVD. Preventive interventions, such as life-style modification, should be offered early even to the apparently healthy elderly. Wolters Kluwer Health 2017-06-23 /pmc/articles/PMC5484226/ /pubmed/28640118 http://dx.doi.org/10.1097/MD.0000000000007227 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4600
Chen, Yen-Lin
Hsu, Chun-Hsien
Hsieh, Chang-Hsun
Wu, Chung-Ze
Lin, Jiunn-Diann
Chang, Jin-Biou
Liang, Yao-Jen
Tsai, Yi-Ting
Hsia, Te-Lin
Pei, Dee
High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study
title High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study
title_full High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study
title_fullStr High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study
title_full_unstemmed High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study
title_short High normotension is associated with future metabolic syndrome but not cardiovascular disease: A 10-year longitudinal study
title_sort high normotension is associated with future metabolic syndrome but not cardiovascular disease: a 10-year longitudinal study
topic 4600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484226/
https://www.ncbi.nlm.nih.gov/pubmed/28640118
http://dx.doi.org/10.1097/MD.0000000000007227
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