Cargando…

Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis

BACKGROUND: Previous case-control studies on association between KCNE1 G38S polymorphism and risk of atrial fibrillation (AF) have been published but because of the conflicting results and small sample size of individual studies, the consolidated result is still controversial. OBJECTIVES: The aim of...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Yu-Feng, Chen, Min, Zhang, Nan-Nan, Yang, Hua-Jia, Xu, Lang-Biao, Rui, Qing, Sun, Si-Jia, Yao, Jia-Lu, Zhou, Ya-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484235/
https://www.ncbi.nlm.nih.gov/pubmed/28640127
http://dx.doi.org/10.1097/MD.0000000000007253
_version_ 1783245843771424768
author Jiang, Yu-Feng
Chen, Min
Zhang, Nan-Nan
Yang, Hua-Jia
Xu, Lang-Biao
Rui, Qing
Sun, Si-Jia
Yao, Jia-Lu
Zhou, Ya-Feng
author_facet Jiang, Yu-Feng
Chen, Min
Zhang, Nan-Nan
Yang, Hua-Jia
Xu, Lang-Biao
Rui, Qing
Sun, Si-Jia
Yao, Jia-Lu
Zhou, Ya-Feng
author_sort Jiang, Yu-Feng
collection PubMed
description BACKGROUND: Previous case-control studies on association between KCNE1 G38S polymorphism and risk of atrial fibrillation (AF) have been published but because of the conflicting results and small sample size of individual studies, the consolidated result is still controversial. OBJECTIVES: The aim of this study was to explore the relationship between KCNE1 G38S polymorphism and risk of AF. METHODS: We performed a comprehensive literature search on PubMed, Embase, OVID, Web of Science, Wan Fang, and CNKI databases up to March 10, 2017 in English and Chinese languages. Two of the authors individually extracted study data and assessed the study quality using Newcastle-Ottawa scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined in different genetic models for evaluation using a random-effect model or fixed-effect model according to interstudy heterogeneity. RESULTS: There were totally 14 independent case-control studies of 2810 patients and 3080 healthy controls included. Significant associations were found between KCNE1 G38S polymorphism and AF in overall population under all genetic models: allelic (OR: 1.34, 95% CI: 1.24–1.45, P < .001), homozygous (OR: 1.90, 95% CI: 1.61–2.24, P < .001), heterozygous (OR: 1.43, 95% CI: 1.21–1.68, P < .001), recessive (OR: 1.42, 95% CI: 1.20–1.69, P < .001), dominant genetic model (OR: 1.62, 95% CI: 1.39–1.89, P < .001). Subgroup analyses indicated similar association in Chinese and white. CONCLUSIONS: The G38S polymorphism in the KCNE1 gene can significantly increase the risk of AF in both Chinese and white.
format Online
Article
Text
id pubmed-5484235
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-54842352017-07-06 Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis Jiang, Yu-Feng Chen, Min Zhang, Nan-Nan Yang, Hua-Jia Xu, Lang-Biao Rui, Qing Sun, Si-Jia Yao, Jia-Lu Zhou, Ya-Feng Medicine (Baltimore) 3400 BACKGROUND: Previous case-control studies on association between KCNE1 G38S polymorphism and risk of atrial fibrillation (AF) have been published but because of the conflicting results and small sample size of individual studies, the consolidated result is still controversial. OBJECTIVES: The aim of this study was to explore the relationship between KCNE1 G38S polymorphism and risk of AF. METHODS: We performed a comprehensive literature search on PubMed, Embase, OVID, Web of Science, Wan Fang, and CNKI databases up to March 10, 2017 in English and Chinese languages. Two of the authors individually extracted study data and assessed the study quality using Newcastle-Ottawa scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined in different genetic models for evaluation using a random-effect model or fixed-effect model according to interstudy heterogeneity. RESULTS: There were totally 14 independent case-control studies of 2810 patients and 3080 healthy controls included. Significant associations were found between KCNE1 G38S polymorphism and AF in overall population under all genetic models: allelic (OR: 1.34, 95% CI: 1.24–1.45, P < .001), homozygous (OR: 1.90, 95% CI: 1.61–2.24, P < .001), heterozygous (OR: 1.43, 95% CI: 1.21–1.68, P < .001), recessive (OR: 1.42, 95% CI: 1.20–1.69, P < .001), dominant genetic model (OR: 1.62, 95% CI: 1.39–1.89, P < .001). Subgroup analyses indicated similar association in Chinese and white. CONCLUSIONS: The G38S polymorphism in the KCNE1 gene can significantly increase the risk of AF in both Chinese and white. Wolters Kluwer Health 2017-06-23 /pmc/articles/PMC5484235/ /pubmed/28640127 http://dx.doi.org/10.1097/MD.0000000000007253 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3400
Jiang, Yu-Feng
Chen, Min
Zhang, Nan-Nan
Yang, Hua-Jia
Xu, Lang-Biao
Rui, Qing
Sun, Si-Jia
Yao, Jia-Lu
Zhou, Ya-Feng
Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis
title Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis
title_full Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis
title_fullStr Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis
title_full_unstemmed Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis
title_short Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation: A PRISMA-compliant meta-analysis
title_sort association between kcne1 g38s gene polymorphism and risk of atrial fibrillation: a prisma-compliant meta-analysis
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484235/
https://www.ncbi.nlm.nih.gov/pubmed/28640127
http://dx.doi.org/10.1097/MD.0000000000007253
work_keys_str_mv AT jiangyufeng associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT chenmin associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT zhangnannan associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT yanghuajia associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT xulangbiao associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT ruiqing associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT sunsijia associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT yaojialu associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis
AT zhouyafeng associationbetweenkcne1g38sgenepolymorphismandriskofatrialfibrillationaprismacompliantmetaanalysis