Cargando…

A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China

BACKGROUND: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered....

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Wanwen, Dong, Mengjie, Zhan, Jun, Yang, Jun, Zhang, Bo, Zhao, Xingdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484247/
https://www.ncbi.nlm.nih.gov/pubmed/28640139
http://dx.doi.org/10.1097/MD.0000000000007279
_version_ 1783245846713729024
author Weng, Wanwen
Dong, Mengjie
Zhan, Jun
Yang, Jun
Zhang, Bo
Zhao, Xingdong
author_facet Weng, Wanwen
Dong, Mengjie
Zhan, Jun
Yang, Jun
Zhang, Bo
Zhao, Xingdong
author_sort Weng, Wanwen
collection PubMed
description BACKGROUND: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered. OBJECTIVE: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China. Furthermore, we aimed to analyze the relationship between thyroid disease and UIC, to provide guidance in establishing effective health policies regarding iodine intake. METHODS: PubMed, Cochrane, Embase, CNKI, Wan fang, and CQVIP databases were searched for random community-based relevant studies with UIC published before January 2016 in mainland China. Two independent reviewers extracted data from eligible citations, and obtained prevalence of thyroid disease for different UICs, as well as the intergroup interaction P values. RESULTS: Forty-three articles were included. The prevalence of thyroid nodules was 22.3% (95% confidence interval [CI]: 20.6%–24.1%) for the low-iodine group, 25.4% (95% CI: 20.8%–28.8%) for the medium-iodine group, and 6.8% (95% CI: 2.8%–11.5%) for the high-iodine group. In the high-iodine group, the prevalence of thyroid nodules was lower than the other groups. The prevalence of 8.3% (95% CI: 3.8%–17.3%) for subclinical hypothyroidism in the high-iodine group was significantly higher than the low- and medium-iodine groups (P < .01). The prevalence of hypothyroidism in the medium-iodine group was 0.2% (95% CI: 0.1%–0.4%), and was lower than the prevalence of the other 2 groups (P < .01). There was no difference in prevalence of hyperthyroidism in each group. CONCLUSIONS: Thyroid nodules are the most easily detectable thyroid disease. These have a lower prevalence in the high-iodine group. The prevalence of most thyroid diseases is lowest for a UIC ranging from 100 to 299 μg/L. This serves as a reference for health policy-making with respect to iodine levels. Further studies on this topic should be carried out according to sufficient thyroid cancer data.
format Online
Article
Text
id pubmed-5484247
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-54842472017-07-06 A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China Weng, Wanwen Dong, Mengjie Zhan, Jun Yang, Jun Zhang, Bo Zhao, Xingdong Medicine (Baltimore) 4300 BACKGROUND: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered. OBJECTIVE: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China. Furthermore, we aimed to analyze the relationship between thyroid disease and UIC, to provide guidance in establishing effective health policies regarding iodine intake. METHODS: PubMed, Cochrane, Embase, CNKI, Wan fang, and CQVIP databases were searched for random community-based relevant studies with UIC published before January 2016 in mainland China. Two independent reviewers extracted data from eligible citations, and obtained prevalence of thyroid disease for different UICs, as well as the intergroup interaction P values. RESULTS: Forty-three articles were included. The prevalence of thyroid nodules was 22.3% (95% confidence interval [CI]: 20.6%–24.1%) for the low-iodine group, 25.4% (95% CI: 20.8%–28.8%) for the medium-iodine group, and 6.8% (95% CI: 2.8%–11.5%) for the high-iodine group. In the high-iodine group, the prevalence of thyroid nodules was lower than the other groups. The prevalence of 8.3% (95% CI: 3.8%–17.3%) for subclinical hypothyroidism in the high-iodine group was significantly higher than the low- and medium-iodine groups (P < .01). The prevalence of hypothyroidism in the medium-iodine group was 0.2% (95% CI: 0.1%–0.4%), and was lower than the prevalence of the other 2 groups (P < .01). There was no difference in prevalence of hyperthyroidism in each group. CONCLUSIONS: Thyroid nodules are the most easily detectable thyroid disease. These have a lower prevalence in the high-iodine group. The prevalence of most thyroid diseases is lowest for a UIC ranging from 100 to 299 μg/L. This serves as a reference for health policy-making with respect to iodine levels. Further studies on this topic should be carried out according to sufficient thyroid cancer data. Wolters Kluwer Health 2017-06-23 /pmc/articles/PMC5484247/ /pubmed/28640139 http://dx.doi.org/10.1097/MD.0000000000007279 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4300
Weng, Wanwen
Dong, Mengjie
Zhan, Jun
Yang, Jun
Zhang, Bo
Zhao, Xingdong
A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China
title A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China
title_full A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China
title_fullStr A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China
title_full_unstemmed A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China
title_short A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China
title_sort prisma-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland china
topic 4300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484247/
https://www.ncbi.nlm.nih.gov/pubmed/28640139
http://dx.doi.org/10.1097/MD.0000000000007279
work_keys_str_mv AT wengwanwen aprismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT dongmengjie aprismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT zhanjun aprismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT yangjun aprismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT zhangbo aprismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT zhaoxingdong aprismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT wengwanwen prismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT dongmengjie prismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT zhanjun prismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT yangjun prismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT zhangbo prismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina
AT zhaoxingdong prismacompliantsystematicreviewandmetaanalysisoftherelationshipbetweenthyroiddiseaseanddifferentlevelsofiodineintakeinmainlandchina