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Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo...

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Autores principales: Ciavatta, Maria Letizia, Lefranc, Florence, Carbone, Marianna, Mollo, Ernesto, Gavagnin, Margherita, Betancourt, Tania, Dasari, Ramesh, Kornienko, Alexander, Kiss, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484305/
https://www.ncbi.nlm.nih.gov/pubmed/27925266
http://dx.doi.org/10.1002/med.21423
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author Ciavatta, Maria Letizia
Lefranc, Florence
Carbone, Marianna
Mollo, Ernesto
Gavagnin, Margherita
Betancourt, Tania
Dasari, Ramesh
Kornienko, Alexander
Kiss, Robert
author_facet Ciavatta, Maria Letizia
Lefranc, Florence
Carbone, Marianna
Mollo, Ernesto
Gavagnin, Margherita
Betancourt, Tania
Dasari, Ramesh
Kornienko, Alexander
Kiss, Robert
author_sort Ciavatta, Maria Letizia
collection PubMed
description The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as “chemotaxonomic markers” for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy. The current review highlights the diversity of chemical structures, mechanisms of action, and, most importantly, the potential of mollusk‐derived metabolites as anticancer agents, including those biosynthesized by mollusks and those of dietary origin. After the discussion of dolastatins and kahalalides, compounds previously studied in clinical trials, the review covers potentially promising anticancer agents, which are grouped based on their structural type and include terpenes, steroids, peptides, polyketides and nitrogen‐containing compounds. The “promise” of a mollusk‐derived natural product as an anticancer agent is evaluated on the basis of its ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. These characteristics include high antiproliferative potency against cancer cells in vitro, preferential inhibition of the proliferation of cancer cells over normal ones, mechanism of action via nonapoptotic signaling pathways, circumvention of multidrug resistance phenotype, and high activity in vivo, among others. The review also includes sections on the targeted delivery of mollusk‐derived anticancer agents and solutions to their procurement in quantity.
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spelling pubmed-54843052017-07-10 Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance Ciavatta, Maria Letizia Lefranc, Florence Carbone, Marianna Mollo, Ernesto Gavagnin, Margherita Betancourt, Tania Dasari, Ramesh Kornienko, Alexander Kiss, Robert Med Res Rev Review Articles The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as “chemotaxonomic markers” for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy. The current review highlights the diversity of chemical structures, mechanisms of action, and, most importantly, the potential of mollusk‐derived metabolites as anticancer agents, including those biosynthesized by mollusks and those of dietary origin. After the discussion of dolastatins and kahalalides, compounds previously studied in clinical trials, the review covers potentially promising anticancer agents, which are grouped based on their structural type and include terpenes, steroids, peptides, polyketides and nitrogen‐containing compounds. The “promise” of a mollusk‐derived natural product as an anticancer agent is evaluated on the basis of its ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. These characteristics include high antiproliferative potency against cancer cells in vitro, preferential inhibition of the proliferation of cancer cells over normal ones, mechanism of action via nonapoptotic signaling pathways, circumvention of multidrug resistance phenotype, and high activity in vivo, among others. The review also includes sections on the targeted delivery of mollusk‐derived anticancer agents and solutions to their procurement in quantity. John Wiley and Sons Inc. 2016-12-07 2017-07 /pmc/articles/PMC5484305/ /pubmed/27925266 http://dx.doi.org/10.1002/med.21423 Text en © 2016 The Authors Medicinal Research Reviews Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Ciavatta, Maria Letizia
Lefranc, Florence
Carbone, Marianna
Mollo, Ernesto
Gavagnin, Margherita
Betancourt, Tania
Dasari, Ramesh
Kornienko, Alexander
Kiss, Robert
Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
title Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
title_full Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
title_fullStr Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
title_full_unstemmed Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
title_short Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
title_sort marine mollusk‐derived agents with antiproliferative activity as promising anticancer agents to overcome chemotherapy resistance
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484305/
https://www.ncbi.nlm.nih.gov/pubmed/27925266
http://dx.doi.org/10.1002/med.21423
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