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Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism
BACKGROUND: The incidence of radiation‐induced hypothyroidism (RIH) in patients with head and neck cancer is >50%. The purpose of this study was to assess the long‐term efficacy of free thyroid transfer (FTT) for prevention of RIH in patients with head and neck cancer. METHODS: Hemithyroid dissec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484331/ https://www.ncbi.nlm.nih.gov/pubmed/27862538 http://dx.doi.org/10.1002/hed.24590 |
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author | Harris, Jeffrey Barber, Brittany Almarzouki, Hani Scrimger, Rufus Romney, Jacques O'Connell, Daniel Urken, Mark Seikaly, Hadi |
author_facet | Harris, Jeffrey Barber, Brittany Almarzouki, Hani Scrimger, Rufus Romney, Jacques O'Connell, Daniel Urken, Mark Seikaly, Hadi |
author_sort | Harris, Jeffrey |
collection | PubMed |
description | BACKGROUND: The incidence of radiation‐induced hypothyroidism (RIH) in patients with head and neck cancer is >50%. The purpose of this study was to assess the long‐term efficacy of free thyroid transfer (FTT) for prevention of RIH in patients with head and neck cancer. METHODS: Hemithyroid dissection was completed in 10 patients with advanced head and neck cancer undergoing ablation, radial forearm free flap (RFFF) reconstruction, and postoperative radiotherapy (RT). The hemithyroid was anastomosed to the donor site vessels in the forearm. Thyroid laboratory testing and technetium (Tc) scans were performed 6 weeks and 12 months postoperatively to establish functional integrity. RESULTS: FTT was successfully performed in 9 of 10 recruited patients. Postoperative Tc scans demonstrated strong Tc uptake in the forearm donor site at 6 weeks and 12 months in all patients who underwent transplantations. CONCLUSION: FTT is feasible with maintenance of function, and may represent a novel strategy for prevention of RIH. © 2016 Elsevier Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 1234–1238, 2017 |
format | Online Article Text |
id | pubmed-5484331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54843312017-07-10 Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism Harris, Jeffrey Barber, Brittany Almarzouki, Hani Scrimger, Rufus Romney, Jacques O'Connell, Daniel Urken, Mark Seikaly, Hadi Head Neck Original Articles BACKGROUND: The incidence of radiation‐induced hypothyroidism (RIH) in patients with head and neck cancer is >50%. The purpose of this study was to assess the long‐term efficacy of free thyroid transfer (FTT) for prevention of RIH in patients with head and neck cancer. METHODS: Hemithyroid dissection was completed in 10 patients with advanced head and neck cancer undergoing ablation, radial forearm free flap (RFFF) reconstruction, and postoperative radiotherapy (RT). The hemithyroid was anastomosed to the donor site vessels in the forearm. Thyroid laboratory testing and technetium (Tc) scans were performed 6 weeks and 12 months postoperatively to establish functional integrity. RESULTS: FTT was successfully performed in 9 of 10 recruited patients. Postoperative Tc scans demonstrated strong Tc uptake in the forearm donor site at 6 weeks and 12 months in all patients who underwent transplantations. CONCLUSION: FTT is feasible with maintenance of function, and may represent a novel strategy for prevention of RIH. © 2016 Elsevier Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 1234–1238, 2017 John Wiley and Sons Inc. 2016-11-15 2017-06 /pmc/articles/PMC5484331/ /pubmed/27862538 http://dx.doi.org/10.1002/hed.24590 Text en © 2016 Elsevier Head & Neck Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Harris, Jeffrey Barber, Brittany Almarzouki, Hani Scrimger, Rufus Romney, Jacques O'Connell, Daniel Urken, Mark Seikaly, Hadi Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
title | Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
title_full | Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
title_fullStr | Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
title_full_unstemmed | Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
title_short | Free thyroid transfer: Short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
title_sort | free thyroid transfer: short‐term results of a novel procedure to prevent post‐radiation hypothyroidism |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484331/ https://www.ncbi.nlm.nih.gov/pubmed/27862538 http://dx.doi.org/10.1002/hed.24590 |
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