Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays

Risk stratification of patients with early stage breast cancer may support adjuvant chemotherapy decision‐making. This review details the development and validation of six multi‐gene classifiers, each of which claims to provide useful prognostic and possibly predictive information for early stage br...

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Detalles Bibliográficos
Autores principales: Hyams, David M., Schuur, Eric, Angel Aristizabal, Javier, Bargallo Rocha, Juan Enrique, Cabello, Cesar, Elizalde, Roberto, García‐Estévez, Laura, Gomez, Henry L., Katz, Artur, Nuñez De Pierro, Aníbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484338/
https://www.ncbi.nlm.nih.gov/pubmed/28211064
http://dx.doi.org/10.1002/jso.24561
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author Hyams, David M.
Schuur, Eric
Angel Aristizabal, Javier
Bargallo Rocha, Juan Enrique
Cabello, Cesar
Elizalde, Roberto
García‐Estévez, Laura
Gomez, Henry L.
Katz, Artur
Nuñez De Pierro, Aníbal
author_facet Hyams, David M.
Schuur, Eric
Angel Aristizabal, Javier
Bargallo Rocha, Juan Enrique
Cabello, Cesar
Elizalde, Roberto
García‐Estévez, Laura
Gomez, Henry L.
Katz, Artur
Nuñez De Pierro, Aníbal
author_sort Hyams, David M.
collection PubMed
description Risk stratification of patients with early stage breast cancer may support adjuvant chemotherapy decision‐making. This review details the development and validation of six multi‐gene classifiers, each of which claims to provide useful prognostic and possibly predictive information for early stage breast cancer patients. A careful assessment is presented of each test's analytical validity, clinical validity, and clinical utility, as well as the quality of evidence supporting its use.
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spelling pubmed-54843382017-07-10 Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays Hyams, David M. Schuur, Eric Angel Aristizabal, Javier Bargallo Rocha, Juan Enrique Cabello, Cesar Elizalde, Roberto García‐Estévez, Laura Gomez, Henry L. Katz, Artur Nuñez De Pierro, Aníbal J Surg Oncol Review Article Risk stratification of patients with early stage breast cancer may support adjuvant chemotherapy decision‐making. This review details the development and validation of six multi‐gene classifiers, each of which claims to provide useful prognostic and possibly predictive information for early stage breast cancer patients. A careful assessment is presented of each test's analytical validity, clinical validity, and clinical utility, as well as the quality of evidence supporting its use. John Wiley and Sons Inc. 2017-02-17 2017-05-01 /pmc/articles/PMC5484338/ /pubmed/28211064 http://dx.doi.org/10.1002/jso.24561 Text en © 2017 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Article
Hyams, David M.
Schuur, Eric
Angel Aristizabal, Javier
Bargallo Rocha, Juan Enrique
Cabello, Cesar
Elizalde, Roberto
García‐Estévez, Laura
Gomez, Henry L.
Katz, Artur
Nuñez De Pierro, Aníbal
Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
title Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
title_full Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
title_fullStr Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
title_full_unstemmed Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
title_short Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
title_sort selecting postoperative adjuvant systemic therapy for early stage breast cancer: a critical assessment of commercially available gene expression assays
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484338/
https://www.ncbi.nlm.nih.gov/pubmed/28211064
http://dx.doi.org/10.1002/jso.24561
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