Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases

The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin, protein homeostasis and membrane trafficking systems are highly integrated. Here, we look at the influence of reversible ubiquitylation on membrane trafficking and organelle dynamics. We review the regulation...

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Detalles Bibliográficos
Autores principales: Clague, Michael J., Urbé, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
State‐of‐the‐Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484354/
https://www.ncbi.nlm.nih.gov/pubmed/28064438
http://dx.doi.org/10.1111/febs.14007
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author Clague, Michael J.
Urbé, Sylvie
author_facet Clague, Michael J.
Urbé, Sylvie
author_sort Clague, Michael J.
collection PubMed
description The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin, protein homeostasis and membrane trafficking systems are highly integrated. Here, we look at the influence of reversible ubiquitylation on membrane trafficking and organelle dynamics. We review the regulation of endocytic sorting, selective autophagy and the secretory pathway by ubiquitin signals, with a particular focus on detailing the contribution of deubiquitylating enzymes.
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spelling pubmed-54843542017-07-10 Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases Clague, Michael J. Urbé, Sylvie FEBS J State‐of‐the‐Art Review The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin, protein homeostasis and membrane trafficking systems are highly integrated. Here, we look at the influence of reversible ubiquitylation on membrane trafficking and organelle dynamics. We review the regulation of endocytic sorting, selective autophagy and the secretory pathway by ubiquitin signals, with a particular focus on detailing the contribution of deubiquitylating enzymes. John Wiley and Sons Inc. 2017-01-29 2017-06 /pmc/articles/PMC5484354/ /pubmed/28064438 http://dx.doi.org/10.1111/febs.14007 Text en © 2017 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle State‐of‐the‐Art Review
Clague, Michael J.
Urbé, Sylvie
Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
title Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
title_full Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
title_fullStr Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
title_full_unstemmed Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
title_short Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
title_sort integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
topic State‐of‐the‐Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484354/
https://www.ncbi.nlm.nih.gov/pubmed/28064438
http://dx.doi.org/10.1111/febs.14007
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