Cargando…

Dendritic Cell Dysfunction in Patients with End-stage Renal Disease

End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ji Ung, Kim, Miyeon, Kim, Sinae, Nguyen, Tam Thanh, Kim, Eunhye, Lee, Siyoung, Kim, Soohyun, Kim, Hyunwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484645/
https://www.ncbi.nlm.nih.gov/pubmed/28680376
http://dx.doi.org/10.4110/in.2017.17.3.152
_version_ 1783245914769457152
author Kim, Ji Ung
Kim, Miyeon
Kim, Sinae
Nguyen, Tam Thanh
Kim, Eunhye
Lee, Siyoung
Kim, Soohyun
Kim, Hyunwoo
author_facet Kim, Ji Ung
Kim, Miyeon
Kim, Sinae
Nguyen, Tam Thanh
Kim, Eunhye
Lee, Siyoung
Kim, Soohyun
Kim, Hyunwoo
author_sort Kim, Ji Ung
collection PubMed
description End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte proliferative response to stimuli, and a malfunction of cell-mediated immunity at the molecular level. ESRD also increases patients' propensity for infections and malignancies as well as causing a diminished response to vaccination. Several factors influence the immunodeficiency in patients with ESRD, including uremic toxins, malnutrition, chronic inflammation, and the therapeutic dialysis modality. The alteration of T-cell function in ESRD has been considered to be a major factor underlying the impaired adaptive cellular immunity in these patients. However, cumulative evidence has suggested that the immune defect in ESRD can be caused by an Ag-presenting dendritic cell (DC) dysfunction in addition to a T-cell defect. It has been reported that ESRD has a deleterious effect on DCs both in terms of their number and function, although the precise mechanism by which DC function becomes altered in these patients is unclear. In this review, we discuss the effects of ESRD on the number and function of DCs and propose a possible molecular mechanism for DC dysfunction. We also address therapeutic approaches to improve immune function by optimally activating DCs in patients with ESRD.
format Online
Article
Text
id pubmed-5484645
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Korean Association of Immunologists
record_format MEDLINE/PubMed
spelling pubmed-54846452017-07-05 Dendritic Cell Dysfunction in Patients with End-stage Renal Disease Kim, Ji Ung Kim, Miyeon Kim, Sinae Nguyen, Tam Thanh Kim, Eunhye Lee, Siyoung Kim, Soohyun Kim, Hyunwoo Immune Netw Review Article End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte proliferative response to stimuli, and a malfunction of cell-mediated immunity at the molecular level. ESRD also increases patients' propensity for infections and malignancies as well as causing a diminished response to vaccination. Several factors influence the immunodeficiency in patients with ESRD, including uremic toxins, malnutrition, chronic inflammation, and the therapeutic dialysis modality. The alteration of T-cell function in ESRD has been considered to be a major factor underlying the impaired adaptive cellular immunity in these patients. However, cumulative evidence has suggested that the immune defect in ESRD can be caused by an Ag-presenting dendritic cell (DC) dysfunction in addition to a T-cell defect. It has been reported that ESRD has a deleterious effect on DCs both in terms of their number and function, although the precise mechanism by which DC function becomes altered in these patients is unclear. In this review, we discuss the effects of ESRD on the number and function of DCs and propose a possible molecular mechanism for DC dysfunction. We also address therapeutic approaches to improve immune function by optimally activating DCs in patients with ESRD. The Korean Association of Immunologists 2017-06 2017-06-20 /pmc/articles/PMC5484645/ /pubmed/28680376 http://dx.doi.org/10.4110/in.2017.17.3.152 Text en Copyright © 2017 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Ji Ung
Kim, Miyeon
Kim, Sinae
Nguyen, Tam Thanh
Kim, Eunhye
Lee, Siyoung
Kim, Soohyun
Kim, Hyunwoo
Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
title Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
title_full Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
title_fullStr Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
title_full_unstemmed Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
title_short Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
title_sort dendritic cell dysfunction in patients with end-stage renal disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484645/
https://www.ncbi.nlm.nih.gov/pubmed/28680376
http://dx.doi.org/10.4110/in.2017.17.3.152
work_keys_str_mv AT kimjiung dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT kimmiyeon dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT kimsinae dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT nguyentamthanh dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT kimeunhye dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT leesiyoung dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT kimsoohyun dendriticcelldysfunctioninpatientswithendstagerenaldisease
AT kimhyunwoo dendriticcelldysfunctioninpatientswithendstagerenaldisease