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Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end-rings an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484665/ https://www.ncbi.nlm.nih.gov/pubmed/28652614 http://dx.doi.org/10.1038/s41598-017-03902-7 |
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author | Zeng, Xianchun Chen, Liangliang Wang, Chuan Wang, Jian Qian, Chunqi |
author_facet | Zeng, Xianchun Chen, Liangliang Wang, Chuan Wang, Jian Qian, Chunqi |
author_sort | Zeng, Xianchun |
collection | PubMed |
description | A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end-rings and two vertical legs to create two orthogonal resonance modes. Based on the principle of parametric amplification, the detector can harvest wireless pumping power with its end-rings and amplify Magnetic Resonance signals induced on its vertical legs. With good longitudinal and azimuthal homogeneity, the WAND can achieve up to 21-times sensitivity gain over a standard external detector for immediately adjacent regions, and at least 5-times sensitivity gain for regions separated by one diameter away from the detector’s cylindrical surface. The WAND can approach the region of interest through the lower digestive track, similar as a colonoscopy detector. But unlike an optical camera, the amplified MR detector can “see” across intestinal boundaries and clearly identify the walls of bifurcated vessels that are susceptible to atherosclerotic lesions. In addition to vascular wall imaging, this detector may also be used as a swallowable capsule to enhance the detection sensitivity of deep-lying organs near the digestive track. |
format | Online Article Text |
id | pubmed-5484665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54846652017-06-30 Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls Zeng, Xianchun Chen, Liangliang Wang, Chuan Wang, Jian Qian, Chunqi Sci Rep Article A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end-rings and two vertical legs to create two orthogonal resonance modes. Based on the principle of parametric amplification, the detector can harvest wireless pumping power with its end-rings and amplify Magnetic Resonance signals induced on its vertical legs. With good longitudinal and azimuthal homogeneity, the WAND can achieve up to 21-times sensitivity gain over a standard external detector for immediately adjacent regions, and at least 5-times sensitivity gain for regions separated by one diameter away from the detector’s cylindrical surface. The WAND can approach the region of interest through the lower digestive track, similar as a colonoscopy detector. But unlike an optical camera, the amplified MR detector can “see” across intestinal boundaries and clearly identify the walls of bifurcated vessels that are susceptible to atherosclerotic lesions. In addition to vascular wall imaging, this detector may also be used as a swallowable capsule to enhance the detection sensitivity of deep-lying organs near the digestive track. Nature Publishing Group UK 2017-06-26 /pmc/articles/PMC5484665/ /pubmed/28652614 http://dx.doi.org/10.1038/s41598-017-03902-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zeng, Xianchun Chen, Liangliang Wang, Chuan Wang, Jian Qian, Chunqi Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls |
title | Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls |
title_full | Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls |
title_fullStr | Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls |
title_full_unstemmed | Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls |
title_short | Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls |
title_sort | wireless mri colonoscopy for sensitive imaging of vascular walls |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484665/ https://www.ncbi.nlm.nih.gov/pubmed/28652614 http://dx.doi.org/10.1038/s41598-017-03902-7 |
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