Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Polycomb repressive complexes (PRCs) are important histone modifiers, which silence gene expression; yet, there exists a subset of PRC-bound genes actively transcribed by RNA polymerase II (RNAPII). It is likely that the role of Polycomb repressive complex is to dampen expression of these PRC-active...

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Detalles Bibliográficos
Autores principales: Kar, Gozde, Kim, Jong Kyoung, Kolodziejczyk, Aleksandra A., Natarajan, Kedar Nath, Torlai Triglia, Elena, Mifsud, Borbala, Elderkin, Sarah, Marioni, John C., Pombo, Ana, Teichmann, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484669/
https://www.ncbi.nlm.nih.gov/pubmed/28652613
http://dx.doi.org/10.1038/s41467-017-00052-2

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