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Congenital deafness is associated with specific somatosensory deficits in adolescents

Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14–20 years old) compared to age...

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Autores principales: Moshourab, Rabih, Bégay, Valérie, Wetzel, Christiane, Walcher, Jan, Middleton, Steven, Gross, Manfred, Lewin, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484691/
https://www.ncbi.nlm.nih.gov/pubmed/28652589
http://dx.doi.org/10.1038/s41598-017-04074-0
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author Moshourab, Rabih
Bégay, Valérie
Wetzel, Christiane
Walcher, Jan
Middleton, Steven
Gross, Manfred
Lewin, Gary R.
author_facet Moshourab, Rabih
Bégay, Valérie
Wetzel, Christiane
Walcher, Jan
Middleton, Steven
Gross, Manfred
Lewin, Gary R.
author_sort Moshourab, Rabih
collection PubMed
description Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14–20 years old) compared to age-matched individuals with congenital hearing loss. Sensory testing was performed on the dominant hand of 111 individuals with normal hearing and 36 with congenital hearing loss. Subjects with congenital deafness were characterized by significantly higher vibration detection thresholds at 10 Hz (2-fold increase, P < 0.001) and 125 Hz (P < 0.05) compared to controls. These sensory changes were not accompanied by any major change in measures of pain perception. We also observed a highly significant reduction (30% compared to controls p < 0.001) in the ability of hearing impaired individual’s ability to detect cooling which was not accompanied by changes in warm detection. At least 60% of children with non-syndromic hearing loss showed very significant loss of vibration detection ability (at 10 Hz) compared to age-matched controls. We thus propose that many pathogenic mutations that cause childhood onset deafness may also play a role in the development or functional maintenance of somatic mechanoreceptors.
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spelling pubmed-54846912017-06-30 Congenital deafness is associated with specific somatosensory deficits in adolescents Moshourab, Rabih Bégay, Valérie Wetzel, Christiane Walcher, Jan Middleton, Steven Gross, Manfred Lewin, Gary R. Sci Rep Article Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14–20 years old) compared to age-matched individuals with congenital hearing loss. Sensory testing was performed on the dominant hand of 111 individuals with normal hearing and 36 with congenital hearing loss. Subjects with congenital deafness were characterized by significantly higher vibration detection thresholds at 10 Hz (2-fold increase, P < 0.001) and 125 Hz (P < 0.05) compared to controls. These sensory changes were not accompanied by any major change in measures of pain perception. We also observed a highly significant reduction (30% compared to controls p < 0.001) in the ability of hearing impaired individual’s ability to detect cooling which was not accompanied by changes in warm detection. At least 60% of children with non-syndromic hearing loss showed very significant loss of vibration detection ability (at 10 Hz) compared to age-matched controls. We thus propose that many pathogenic mutations that cause childhood onset deafness may also play a role in the development or functional maintenance of somatic mechanoreceptors. Nature Publishing Group UK 2017-06-26 /pmc/articles/PMC5484691/ /pubmed/28652589 http://dx.doi.org/10.1038/s41598-017-04074-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moshourab, Rabih
Bégay, Valérie
Wetzel, Christiane
Walcher, Jan
Middleton, Steven
Gross, Manfred
Lewin, Gary R.
Congenital deafness is associated with specific somatosensory deficits in adolescents
title Congenital deafness is associated with specific somatosensory deficits in adolescents
title_full Congenital deafness is associated with specific somatosensory deficits in adolescents
title_fullStr Congenital deafness is associated with specific somatosensory deficits in adolescents
title_full_unstemmed Congenital deafness is associated with specific somatosensory deficits in adolescents
title_short Congenital deafness is associated with specific somatosensory deficits in adolescents
title_sort congenital deafness is associated with specific somatosensory deficits in adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484691/
https://www.ncbi.nlm.nih.gov/pubmed/28652589
http://dx.doi.org/10.1038/s41598-017-04074-0
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