Cargando…

Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood cells preferentially recruit Disc large homolog 1 (Dlgh1) and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zanin-Zhorov, Alexandra, Kumari, Sudha, Hippen, Keli L., Merkel, Sarah C., MacMillan, Margaret L., Blazar, Bruce R., Dustin, Michael L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484704/ https://www.ncbi.nlm.nih.gov/pubmed/28652577 http://dx.doi.org/10.1038/s41598-017-04053-5

Ejemplares similares

Author Correction: Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity
por: Zanin-Zhorov, Alexandra, et al.
Publicado: (2020)

Intervention of PKC-θ as an immunosuppressive regimen
por: Sun, Zuoming
Publicado: (2012)

Emerging translational strategies and challenges for enhancing regulatory T cell therapy for graft-versus-host disease
por: Hippen, Keli L., et al.
Publicado: (2022)

Regulating the Regulator: Phosphorylation of PKC θ in T Cells
por: Freeley, Michael, et al.
Publicado: (2012)

The Novel PKCθ from Benchtop to Clinic
por: Hage-Sleiman, Rouba, et al.
Publicado: (2015)

PKCθ Signals Activation versus Tolerance In Vivo
por: Berg-Brown, Nancy N., et al.
Publicado: (2004)

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity
por: Anel, Alberto, et al.
Publicado: (2012)

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
por: Hippen, Keli L., et al.
Publicado: (2018)

Regulation of PKC-θ function by phosphorylation in T cell receptor signaling
por: Wang, Xiaohong, et al.
Publicado: (2012)

Targeting PKCθ Promotes Satellite Cell Self-Renewal
por: Benedetti, Anna, et al.
Publicado: (2020)

Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development
por: Rivera, Charlene, et al.
Publicado: (2013)

Prediction of PKCθ Inhibitory Activity Using the Random Forest Algorithm
por: Hao, Ming, et al.
Publicado: (2010)

PKCθ Regulates T Cell Motility via Ezrin-Radixin-Moesin Localization to the Uropod
por: Cannon, Judy L., et al.
Publicado: (2013)

Embryonic Stem Cell-Derived Factors Inhibit T Effector Activation and Induce T Regulatory Cells by Suppressing PKC-θ Activation
por: Mohib, Kanishka, et al.
Publicado: (2012)

An active kinase domain is required for retention of PKCθ at the T cell immunological synapse
por: Cartwright, Natalia G., et al.
Publicado: (2011)

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
por: Round, June L., et al.
Publicado: (2005)

PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells
por: López-Huertas, María Rosa, et al.
Publicado: (2016)

TNFa alter cholesterol metabolism in human macrophages via PKC-θ-dependent pathway
por: Sha Ma, A Zhi, et al.
Publicado: (2013)

The Role of PKC-θ in CD4+ T Cells and HIV Infection: To the Nucleus and Back Again
por: Phetsouphanh, Chansavath, et al.
Publicado: (2015)

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent
por: Sourbier, Carole, et al.
Publicado: (2015)

PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species
por: Giambra, Vincenzo, et al.
Publicado: (2012)

Loss-of-function phenotype of a PKCθ(T219A) knockin mouse strain
por: Thuille, Nikolaus, et al.
Publicado: (2019)

Pharmacological Inhibition of PKCθ Counteracts Muscle Disease in a Mouse Model of Duchenne Muscular Dystrophy
por: Marrocco, V., et al.
Publicado: (2017)

Isoform-specific targeting of ROCK proteins in immune cells
por: Zanin-Zhorov, Alexandra, et al.
Publicado: (2016)

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets
por: Tanimine, Naoki, et al.
Publicado: (2019)

Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential
por: Bronk, Crystina C., et al.
Publicado: (2012)

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton
por: Britton, Graham J, et al.
Publicado: (2017)

Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury
por: Fiore, Piera Filomena, et al.
Publicado: (2020)

Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity
por: Ben-Shmuel, Aviad, et al.
Publicado: (2022)

Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals
por: Zanin-Zhorov, Alexandra, et al.
Publicado: (2013)

Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity
por: Barber, Casey N., et al.
Publicado: (2022)

PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability
por: Kang, Jung-Ah, et al.
Publicado: (2017)

PKCθ utility in diagnosing c-KIT/DOG-1 double negative gastrointestinal stromal tumors
por: Kövecsi, Attila, et al.
Publicado: (2017)

Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
por: Morroni, Jacopo, et al.
Publicado: (2022)

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses
por: Clement, Rachel L., et al.
Publicado: (2019)

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
por: Liu, Bing, et al.
Publicado: (2019)

Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4(+) T cells through p65 and H2B phosphorylation
por: Li, Jasmine, et al.
Publicado: (2016)

PKCθ is necessary for efficient activation of NFκB, NFAT, and AP-1 during positive selection of thymocytes
por: Gruber, Thomas, et al.
Publicado: (2010)

Regulation of the PKCθ-NF-κB Axis in T Lymphocytes by the Tumor Necrosis Factor Receptor Family Member OX40
por: So, Takanori, et al.
Publicado: (2012)

PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization
por: Kumar, Raj, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r5m3lh9gpn29flq1e2fgacb5aj