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Nuclear Magnetic Resonance (NMR) Study for the Detection and Quantitation of Cholesterol in HSV529 Therapeutic Vaccine Candidate

This study describes the NMR-based method to determine the limit of quantitation (LOQ) and limit of detection (LOD) of cholesterol, a process-related impurity in the replication-deficient Herpes Simplex Virus (HSV) type 2 candidate vaccine HSV529. Three signature peaks from the 1D (1)H NMR of a chol...

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Detalles Bibliográficos
Autores principales:	Khatun, Rahima, Hunter, Howard, Magcalas, Webster, Sheng, Yi, Carpick, Bruce, Kirkitadze, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484764/ https://www.ncbi.nlm.nih.gov/pubmed/28694932 http://dx.doi.org/10.1016/j.csbj.2016.10.007

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