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Botulinum toxin for treatment of restrictive strabismus()

PURPOSE: To study the types of acquired restrictive strabismus treated in a tertiary hospital and the outcome of treatment with botulinum toxin. METHODS: We performed a 10-year retrospective study of patients with restrictive strabismus aged ≥18 years who were treated with botulinum toxin. Treatment...

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Autores principales: Merino, Pilar S., Vera, Rebeca E., Mariñas, Laura G., Gómez de Liaño, Pilar S., Escribano, Jose V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484785/
https://www.ncbi.nlm.nih.gov/pubmed/27771241
http://dx.doi.org/10.1016/j.optom.2016.09.001
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author Merino, Pilar S.
Vera, Rebeca E.
Mariñas, Laura G.
Gómez de Liaño, Pilar S.
Escribano, Jose V.
author_facet Merino, Pilar S.
Vera, Rebeca E.
Mariñas, Laura G.
Gómez de Liaño, Pilar S.
Escribano, Jose V.
author_sort Merino, Pilar S.
collection PubMed
description PURPOSE: To study the types of acquired restrictive strabismus treated in a tertiary hospital and the outcome of treatment with botulinum toxin. METHODS: We performed a 10-year retrospective study of patients with restrictive strabismus aged ≥18 years who were treated with botulinum toxin. Treatment was considered successful if the final vertical deviation was ≤5 PD, horizontal deviation ≤10 PD, with no head turn or diplopia. RESULTS: We included 27 cases (mean age, 61.9 years). Horizontal strabismus was diagnosed in 11.1%, vertical in 51.9%, and mixed in 37%. Strabismus was secondary to cataract surgery in 6 cases, high myopia in 6, orbital fractures in 5, retinal surgery in 5, Graves ophthalmopathy in 4, and repair of conjunctival injury in 1 case. Diplopia was diagnosed in all patients, head turn in 33.3%. The initial deviation was 14 PD (range, 2–40), the mean number of injections per patient was 1.6 (range, 1–3), and the mean dose was 9.5 IU (range, 2.5–22.5). At the end of follow-up, diplopia was recorded in 59.3%, head turn in 18.5%, surgical treatment in 51.9%, and need for prism glasses in 14.8%. Outcome was successful in 37% of patients (4 high myopia, 3 orbital fractures, 2 post-surgical retinal detachment, and 1 post-cataract surgery). Mean follow-up was 3 ± 1.8 years. CONCLUSION: Vertical deviation was observed in half of the sample. The most frequent deviation was secondary to cataract surgery and high myopia. Treatment with botulinum toxin was successful in one-third of the patients at the end of follow-up.
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spelling pubmed-54847852017-07-10 Botulinum toxin for treatment of restrictive strabismus() Merino, Pilar S. Vera, Rebeca E. Mariñas, Laura G. Gómez de Liaño, Pilar S. Escribano, Jose V. J Optom Original Article PURPOSE: To study the types of acquired restrictive strabismus treated in a tertiary hospital and the outcome of treatment with botulinum toxin. METHODS: We performed a 10-year retrospective study of patients with restrictive strabismus aged ≥18 years who were treated with botulinum toxin. Treatment was considered successful if the final vertical deviation was ≤5 PD, horizontal deviation ≤10 PD, with no head turn or diplopia. RESULTS: We included 27 cases (mean age, 61.9 years). Horizontal strabismus was diagnosed in 11.1%, vertical in 51.9%, and mixed in 37%. Strabismus was secondary to cataract surgery in 6 cases, high myopia in 6, orbital fractures in 5, retinal surgery in 5, Graves ophthalmopathy in 4, and repair of conjunctival injury in 1 case. Diplopia was diagnosed in all patients, head turn in 33.3%. The initial deviation was 14 PD (range, 2–40), the mean number of injections per patient was 1.6 (range, 1–3), and the mean dose was 9.5 IU (range, 2.5–22.5). At the end of follow-up, diplopia was recorded in 59.3%, head turn in 18.5%, surgical treatment in 51.9%, and need for prism glasses in 14.8%. Outcome was successful in 37% of patients (4 high myopia, 3 orbital fractures, 2 post-surgical retinal detachment, and 1 post-cataract surgery). Mean follow-up was 3 ± 1.8 years. CONCLUSION: Vertical deviation was observed in half of the sample. The most frequent deviation was secondary to cataract surgery and high myopia. Treatment with botulinum toxin was successful in one-third of the patients at the end of follow-up. Elsevier 2017 2016-10-19 /pmc/articles/PMC5484785/ /pubmed/27771241 http://dx.doi.org/10.1016/j.optom.2016.09.001 Text en © 2016 Spanish General Council of Optometry. Published by Elsevier Espa˜na, S.L.U. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Merino, Pilar S.
Vera, Rebeca E.
Mariñas, Laura G.
Gómez de Liaño, Pilar S.
Escribano, Jose V.
Botulinum toxin for treatment of restrictive strabismus()
title Botulinum toxin for treatment of restrictive strabismus()
title_full Botulinum toxin for treatment of restrictive strabismus()
title_fullStr Botulinum toxin for treatment of restrictive strabismus()
title_full_unstemmed Botulinum toxin for treatment of restrictive strabismus()
title_short Botulinum toxin for treatment of restrictive strabismus()
title_sort botulinum toxin for treatment of restrictive strabismus()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484785/
https://www.ncbi.nlm.nih.gov/pubmed/27771241
http://dx.doi.org/10.1016/j.optom.2016.09.001
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