Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate

Mutations in the glucocerebrosidase 1 (GBA1) gene are related to both Parkinson disease (PD) and Gaucher disease (GD). In both cases, the condition is associated with deficiency of glucocerebrosidase (GCase), the enzyme encoded by GBA1. Ambroxol is a small molecule chaperone that has been shown in m...

Descripción completa

Detalles Bibliográficos
Autores principales: Migdalska‐Richards, Anna, Ko, Wai Kin D., Li, Qin, Bezard, Erwan, Schapira, Anthony H. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485051/
https://www.ncbi.nlm.nih.gov/pubmed/28295625
http://dx.doi.org/10.1002/syn.21967

Ejemplares similares

Ejemplares similares