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Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis

Secukinumab is a human monoclonal antibody with demonstrated efficacy for moderate to severe psoriasis; it binds to and neutralizes interleukin (IL)‐17A. The pharmacokinetic (PK) parameters of secukinumab were best described by a 2‐compartment model. Only weight was included in the final model, as o...

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Detalles Bibliográficos
Autores principales:	Bruin, Gerard, Loesche, Christian, Nyirady, Judit, Sander, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Pharmacometrics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485066/ https://www.ncbi.nlm.nih.gov/pubmed/28273356 http://dx.doi.org/10.1002/jcph.876

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