Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL

The hypoxia-regulated tumor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor α (HIFα) being its most notable substrate. Here we report that VHL has an equally important fu...

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Detalles Bibliográficos
Autores principales: Hasanov, E, Chen, G, Chowdhury, P, Weldon, J, Ding, Z, Jonasch, E, Sen, S, Walker, C L, Dere, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485216/
https://www.ncbi.nlm.nih.gov/pubmed/28114281
http://dx.doi.org/10.1038/onc.2016.495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485216/
https://www.ncbi.nlm.nih.gov/pubmed/28114281
http://dx.doi.org/10.1038/onc.2016.495

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