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Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding
Ewing's sarcoma is a primary bone cancer that mainly affects the long bones. This malignancy is particularly common in pediatric patients. Primary cranial involvement accounts for 1% of cases, with occipital involvement considered extremely rare. In this case study, primary occipital Ewing'...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485299/ https://www.ncbi.nlm.nih.gov/pubmed/28690908 http://dx.doi.org/10.1155/2017/1521407 |
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author | Alqahtani, Ali Amer, Roaa Bakhsh, Eman |
author_facet | Alqahtani, Ali Amer, Roaa Bakhsh, Eman |
author_sort | Alqahtani, Ali |
collection | PubMed |
description | Ewing's sarcoma is a primary bone cancer that mainly affects the long bones. This malignancy is particularly common in pediatric patients. Primary cranial involvement accounts for 1% of cases, with occipital involvement considered extremely rare. In this case study, primary occipital Ewing's sarcoma with a posterior fossa mass and subsequent relapse resulting in spinal seeding is reported. A 3-year-old patient presented with a 1-year history of left-sided headaches, localized over the occipital bone with progressive torticollis. Computed tomography (CT) imaging showed a mass in the left posterior fossa compressing the brainstem. The patient then underwent surgical excision followed by adjuvant chemoradiation therapy. Two years later, the patient presented with severe lower back pain and urinary incontinence. Whole-spine magnetic resonance imaging (MRI) showed cerebrospinal fluid (CSF) seeding from the L5 to the S4 vertebrae. Primary cranial Ewing's sarcoma is considered in the differential diagnosis of children with extra-axial posterior fossa mass associated with destructive permeative bone lesions. Although primary cranial Ewing's sarcoma typically has good prognosis, our patient developed metastasis in the lower spine. Therefore, with CNS Ewing's sarcoma, screening of the entire neural axis should be taken into consideration for early detection of CSF seeding metastasis in order to decrease the associated morbidity and mortality. |
format | Online Article Text |
id | pubmed-5485299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54852992017-07-09 Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding Alqahtani, Ali Amer, Roaa Bakhsh, Eman Case Rep Pediatr Case Report Ewing's sarcoma is a primary bone cancer that mainly affects the long bones. This malignancy is particularly common in pediatric patients. Primary cranial involvement accounts for 1% of cases, with occipital involvement considered extremely rare. In this case study, primary occipital Ewing's sarcoma with a posterior fossa mass and subsequent relapse resulting in spinal seeding is reported. A 3-year-old patient presented with a 1-year history of left-sided headaches, localized over the occipital bone with progressive torticollis. Computed tomography (CT) imaging showed a mass in the left posterior fossa compressing the brainstem. The patient then underwent surgical excision followed by adjuvant chemoradiation therapy. Two years later, the patient presented with severe lower back pain and urinary incontinence. Whole-spine magnetic resonance imaging (MRI) showed cerebrospinal fluid (CSF) seeding from the L5 to the S4 vertebrae. Primary cranial Ewing's sarcoma is considered in the differential diagnosis of children with extra-axial posterior fossa mass associated with destructive permeative bone lesions. Although primary cranial Ewing's sarcoma typically has good prognosis, our patient developed metastasis in the lower spine. Therefore, with CNS Ewing's sarcoma, screening of the entire neural axis should be taken into consideration for early detection of CSF seeding metastasis in order to decrease the associated morbidity and mortality. Hindawi 2017 2017-06-13 /pmc/articles/PMC5485299/ /pubmed/28690908 http://dx.doi.org/10.1155/2017/1521407 Text en Copyright © 2017 Ali Alqahtani et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Alqahtani, Ali Amer, Roaa Bakhsh, Eman Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding |
title | Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding |
title_full | Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding |
title_fullStr | Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding |
title_full_unstemmed | Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding |
title_short | Primary Occipital Ewing's Sarcoma with Subsequent Spinal Seeding |
title_sort | primary occipital ewing's sarcoma with subsequent spinal seeding |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485299/ https://www.ncbi.nlm.nih.gov/pubmed/28690908 http://dx.doi.org/10.1155/2017/1521407 |
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