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Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers

[Image: see text] We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm dist...

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Detalles Bibliográficos
Autores principales: Zafarani, Hamid Reza, Mathwig, Klaus, Sudhölter, Ernst J. R., Rassaei, Liza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485373/
https://www.ncbi.nlm.nih.gov/pubmed/28670622
http://dx.doi.org/10.1021/acssensors.7b00180
Descripción
Sumario:[Image: see text] We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We demonstrate a current amplification factor of 2.5 as well as the possibility to detect the signal of only 60 analyte molecules occupying the detection volume. Experimental voltammetry results are compared to calculations from finite element analysis.