Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers

[Image: see text] We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm dist...

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Autores principales: Zafarani, Hamid Reza, Mathwig, Klaus, Sudhölter, Ernst J. R., Rassaei, Liza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485373/
https://www.ncbi.nlm.nih.gov/pubmed/28670622
http://dx.doi.org/10.1021/acssensors.7b00180
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author Zafarani, Hamid Reza
Mathwig, Klaus
Sudhölter, Ernst J. R.
Rassaei, Liza
author_facet Zafarani, Hamid Reza
Mathwig, Klaus
Sudhölter, Ernst J. R.
Rassaei, Liza
author_sort Zafarani, Hamid Reza
collection PubMed
description [Image: see text] We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We demonstrate a current amplification factor of 2.5 as well as the possibility to detect the signal of only 60 analyte molecules occupying the detection volume. Experimental voltammetry results are compared to calculations from finite element analysis.
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spelling pubmed-54853732017-06-28 Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers Zafarani, Hamid Reza Mathwig, Klaus Sudhölter, Ernst J. R. Rassaei, Liza ACS Sens [Image: see text] We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We demonstrate a current amplification factor of 2.5 as well as the possibility to detect the signal of only 60 analyte molecules occupying the detection volume. Experimental voltammetry results are compared to calculations from finite element analysis. American Chemical Society 2017-05-16 2017-06-23 /pmc/articles/PMC5485373/ /pubmed/28670622 http://dx.doi.org/10.1021/acssensors.7b00180 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Zafarani, Hamid Reza
Mathwig, Klaus
Sudhölter, Ernst J. R.
Rassaei, Liza
Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers
title Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers
title_full Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers
title_fullStr Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers
title_full_unstemmed Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers
title_short Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers
title_sort electrochemical amplification in side-by-side attoliter nanogap transducers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485373/
https://www.ncbi.nlm.nih.gov/pubmed/28670622
http://dx.doi.org/10.1021/acssensors.7b00180
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AT sudholterernstjr electrochemicalamplificationinsidebysideattoliternanogaptransducers
AT rassaeiliza electrochemicalamplificationinsidebysideattoliternanogaptransducers

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