Cargando…

“Self-repairing” nanoshell for cell protection

Self-repair is nature's way of protecting living organisms. However, most single cells are inherently less capable of self-repairing, which greatly limits their wide applications. Here, we present a self-assembly approach to create a nanoshell around the cell surface using nanoporous biohybrid...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Nan, Yang, Xiao-Yu, Ying, Guo-Liang, Shen, Ling, Liu, Jing, Geng, Wei, Dai, Ling-Jun, Liu, Shao-Yin, Cao, Jian, Tian, Ge, Sun, Tao-Lei, Li, Shi-Pu, Su, Bao-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485398/
https://www.ncbi.nlm.nih.gov/pubmed/28694942
http://dx.doi.org/10.1039/c4sc02638a
_version_ 1783246054809927680
author Jiang, Nan
Yang, Xiao-Yu
Ying, Guo-Liang
Shen, Ling
Liu, Jing
Geng, Wei
Dai, Ling-Jun
Liu, Shao-Yin
Cao, Jian
Tian, Ge
Sun, Tao-Lei
Li, Shi-Pu
Su, Bao-Lian
author_facet Jiang, Nan
Yang, Xiao-Yu
Ying, Guo-Liang
Shen, Ling
Liu, Jing
Geng, Wei
Dai, Ling-Jun
Liu, Shao-Yin
Cao, Jian
Tian, Ge
Sun, Tao-Lei
Li, Shi-Pu
Su, Bao-Lian
author_sort Jiang, Nan
collection PubMed
description Self-repair is nature's way of protecting living organisms. However, most single cells are inherently less capable of self-repairing, which greatly limits their wide applications. Here, we present a self-assembly approach to create a nanoshell around the cell surface using nanoporous biohybrid aggregates. The biohybrid shells present self-repairing behaviour, resulting in high activity and extended viability of the encapsulated cells (eukaryotic and prokaryotic cells) in harsh micro-environments, such as under UV radiation, natural toxin invasion, high-light radiation and abrupt pH-value changes. Furthermore, an interaction mechanism is proposed and studied, which is successful to guide design and synthesis of self-repairing biohybrid shells using different bioactive molecules.
format Online
Article
Text
id pubmed-5485398
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-54853982017-07-10 “Self-repairing” nanoshell for cell protection Jiang, Nan Yang, Xiao-Yu Ying, Guo-Liang Shen, Ling Liu, Jing Geng, Wei Dai, Ling-Jun Liu, Shao-Yin Cao, Jian Tian, Ge Sun, Tao-Lei Li, Shi-Pu Su, Bao-Lian Chem Sci Chemistry Self-repair is nature's way of protecting living organisms. However, most single cells are inherently less capable of self-repairing, which greatly limits their wide applications. Here, we present a self-assembly approach to create a nanoshell around the cell surface using nanoporous biohybrid aggregates. The biohybrid shells present self-repairing behaviour, resulting in high activity and extended viability of the encapsulated cells (eukaryotic and prokaryotic cells) in harsh micro-environments, such as under UV radiation, natural toxin invasion, high-light radiation and abrupt pH-value changes. Furthermore, an interaction mechanism is proposed and studied, which is successful to guide design and synthesis of self-repairing biohybrid shells using different bioactive molecules. Royal Society of Chemistry 2015-01-01 2014-10-17 /pmc/articles/PMC5485398/ /pubmed/28694942 http://dx.doi.org/10.1039/c4sc02638a Text en This journal is © The Royal Society of Chemistry 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Jiang, Nan
Yang, Xiao-Yu
Ying, Guo-Liang
Shen, Ling
Liu, Jing
Geng, Wei
Dai, Ling-Jun
Liu, Shao-Yin
Cao, Jian
Tian, Ge
Sun, Tao-Lei
Li, Shi-Pu
Su, Bao-Lian
“Self-repairing” nanoshell for cell protection
title “Self-repairing” nanoshell for cell protection
title_full “Self-repairing” nanoshell for cell protection
title_fullStr “Self-repairing” nanoshell for cell protection
title_full_unstemmed “Self-repairing” nanoshell for cell protection
title_short “Self-repairing” nanoshell for cell protection
title_sort “self-repairing” nanoshell for cell protection
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485398/
https://www.ncbi.nlm.nih.gov/pubmed/28694942
http://dx.doi.org/10.1039/c4sc02638a
work_keys_str_mv AT jiangnan selfrepairingnanoshellforcellprotection
AT yangxiaoyu selfrepairingnanoshellforcellprotection
AT yingguoliang selfrepairingnanoshellforcellprotection
AT shenling selfrepairingnanoshellforcellprotection
AT liujing selfrepairingnanoshellforcellprotection
AT gengwei selfrepairingnanoshellforcellprotection
AT dailingjun selfrepairingnanoshellforcellprotection
AT liushaoyin selfrepairingnanoshellforcellprotection
AT caojian selfrepairingnanoshellforcellprotection
AT tiange selfrepairingnanoshellforcellprotection
AT suntaolei selfrepairingnanoshellforcellprotection
AT lishipu selfrepairingnanoshellforcellprotection
AT subaolian selfrepairingnanoshellforcellprotection