Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers

Junctophilin (JPH) proteins stabilize junctional membrane complexes between plasma membrane and endoplasmic reticulum, also implicated in some human diseases. JPH3 mutations are linked to Huntington's disease-like 2 syndrome. Through epigenomic study of a colon cancer cell line pair (HCT116 and...

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Detalles Bibliográficos
Autores principales: Hu, Xiaotong, Kuang, Yeye, Li, Lili, Tang, Haimei, Shi, Qinglan, Shu, Xingsheng, Zhang, Yanjiao, Chan, Francis KL, Tao, Qian, He, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485426/
https://www.ncbi.nlm.nih.gov/pubmed/28656064
http://dx.doi.org/10.7150/thno.18185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485426/
https://www.ncbi.nlm.nih.gov/pubmed/28656064
http://dx.doi.org/10.7150/thno.18185

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