Cargando…

Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers

Junctophilin (JPH) proteins stabilize junctional membrane complexes between plasma membrane and endoplasmic reticulum, also implicated in some human diseases. JPH3 mutations are linked to Huntington's disease-like 2 syndrome. Through epigenomic study of a colon cancer cell line pair (HCT116 and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Xiaotong, Kuang, Yeye, Li, Lili, Tang, Haimei, Shi, Qinglan, Shu, Xingsheng, Zhang, Yanjiao, Chan, Francis KL, Tao, Qian, He, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485426/ https://www.ncbi.nlm.nih.gov/pubmed/28656064 http://dx.doi.org/10.7150/thno.18185

Ejemplares similares

Heterozygous junctophilin-2 (JPH2) p.(Thr161Lys) is a monogenic cause for HCM with heart failure
por: Vanninen, Sari U. M., et al.
Publicado: (2018)

CpG Island Mapping by Epigenome Prediction
por: Bock, Christoph, et al.
Publicado: (2007)

Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy
por: Jones, Edward G., et al.
Publicado: (2019)

DNA methylation in human epigenomes depends on local topology of CpG sites
por: Lövkvist, Cecilia, et al.
Publicado: (2016)

Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
por: Bae, Min Gyun, et al.
Publicado: (2016)

Linking the Epigenome to the Genome: Correlation of Different Features to DNA Methylation of CpG Islands
por: Wrzodek, Clemens, et al.
Publicado: (2012)

Epigenome-wide association study reveals CpG sites related to COG of neuroblastoma
por: Zhao, Hao, et al.
Publicado: (2020)

Ca(2+) Microdomains Organized by Junctophilins
por: Takeshima, Hiroshi, et al.
Publicado: (2015)

The role of junctophilin proteins in cellular function
por: Lehnart, Stephan E., et al.
Publicado: (2022)

Effect of CpG ODN on monocytic myeloid derived suppressor cells
por: Shirota, Hidekazu, et al.
Publicado: (2012)

Methylation-associated inactivation of JPH3 and its effect on prognosis and cell biological function in HCC
por: Huang, Yi, et al.
Publicado: (2022)

The Builders of the Junction: Roles of Junctophilin1 and Junctophilin2 in the Assembly of the Sarcoplasmic Reticulum–Plasma Membrane Junctions in Striated Muscle
por: Perni, Stefano
Publicado: (2022)

Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
por: Luo, Xiangyu, et al.
Publicado: (2019)

Junctophilins: Key Membrane Tethers in Muscles and Neurons
por: Piggott, Christopher A., et al.
Publicado: (2021)

Both Heterozygous and Homozygous Loss‐of‐Function JPH3 Variants Are Associated with a Paroxysmal Movement Disorder
por: Steel, Dora, et al.
Publicado: (2022)

Effects of CpG Methylation on Recognition of DNA by the Tumour Suppressor p53
por: Petrovich, Miriana, et al.
Publicado: (2009)

Insights into the Transport Cycle of LAT1 and Interaction with the Inhibitor JPH203
por: Brunocilla, Chiara, et al.
Publicado: (2023)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

CpG Sites Associated with Cigarette Smoking: Analysis of Epigenome-Wide Data from the Sister Study
por: Harlid, Sophia, et al.
Publicado: (2014)

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion
por: Li, L, et al.
Publicado: (2016)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas
por: Li, Lili, et al.
Publicado: (2018)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas: Erratum
por: Li, Lili, et al.
Publicado: (2022)

Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation
por: Quraishi, B. M., et al.
Publicado: (2015)

A Comparative Study of Five Association Tests Based on CpG Set for Epigenome-Wide Association Studies
por: Zhang, Qiuyi, et al.
Publicado: (2016)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers
por: Ying, J, et al.
Publicado: (2009)

CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response
por: Liu, Shuiping, et al.
Publicado: (2017)

DNA methylation determines nucleosome occupancy in the 5′-CpG islands of tumor suppressor genes
por: Portela, A, et al.
Publicado: (2013)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas
por: Wang, Zhaohui, et al.
Publicado: (2012)

CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies
por: Sánchez-Vega, Francisco, et al.
Publicado: (2017)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
por: Endoh, M, et al.
Publicado: (2005)

CpGIF: an algorithm for the identification of CpG islands
por: Sujuan, Ye, et al.
Publicado: (2008)

Identification of novel hyper- or hypomethylated CpG sites and genes associated with atherosclerotic plaque using an epigenome-wide association study
por: Yamada, Yoshiji, et al.
Publicado: (2018)

Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart
por: Hou, Yufeng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tev6ebi93r28uel80cdi42krs1