Erythromycin Modification That Improves Its Acidic Stability while Optimizing It for Local Drug Delivery

The antibiotic erythromycin has limited efficacy and bioavailability due to its instability and conversion under acidic conditions via an intramolecular dehydration reaction. To improve the stability of erythromycin, several analogs have been developed—such as azithromycin and clarithromycin—which d...

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Detalles Bibliográficos
Autores principales: Cyphert, Erika L., Wallat, Jaqueline D., Pokorski, Jonathan K., von Recum, Horst A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485444/
https://www.ncbi.nlm.nih.gov/pubmed/28441360
http://dx.doi.org/10.3390/antibiotics6020011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485444/
https://www.ncbi.nlm.nih.gov/pubmed/28441360
http://dx.doi.org/10.3390/antibiotics6020011

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